Sonic Hedgehog Signalling during Tooth Morphogenesis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007

AUTHORS

Martyn T. Cobourne , Isabelle Miletich , Paul T. Sharpe

ABSTRACT

The Sonic hedgehog (Shh) peptide belongs to a small family of signalling molecules that have a complex mode of action and wide range of function during normal vertebrate development. In common with many regions of the embryo, Shh is expressed in the developing tooth in a regionally restricted manner. Specifically, Shh expression is localised to the epithelial component of the tooth germ at various stages during the odontogenic process; however, both tooth-forming epithelium and mesenchyme are responsive to the signal. A number of studies have analysed the role of Shh during tooth development, utilising both culture based and genetic systems, and it is dear that this signalling pathway is essential for normal development of the tooth. During the initiation of odontogenesis, localised signalling is important for growth and development of the tooth bud, whilst later during morphogenesis, Shh plays a role in cellular differentiation and polarization in the epithelial component of the tooth germ. These complex interactions are mediated by intra-epithelial and epithelial-mesenchymal signalling by Shh throughout these stages of tooth development. More... »

PAGES

69-78

Book

TITLE

Shh and Gli Signalling and Development

ISBN

978-0-387-39956-0
978-0-387-39957-7

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-0-387-39957-7_7

DOI

http://dx.doi.org/10.1007/978-0-387-39957-7_7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041127083


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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-39957-7_7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-39957-7_7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-39957-7_7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-39957-7_7'


 

This table displays all metadata directly associated to this object as RDF triples.

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