Gene Therapy for Parkinson’s Disease Using Aav Vectors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2002

AUTHORS

Keiya Ozawa , Shin-ichi Muramatsu , Ken-ichi Fujimoto , Kunihiko Ikeguchi , Yang Shen , Lijun Wang , Takashi Okada , Hiroaki Mizukami , Yutaka Hanazono , Akihiro Kume , Hiroshi Ichinose , Toshiharu Nagatsu , Keiji Terao , Imaharu Nakano

ABSTRACT

Parkinson’s disease (PD) is a common disorder characterized by progressive disturbance in the control of movement, and the symptoms result from a progressive loss of dopaminergic neurons in the substantia nigra. These neurons send dopamine down to their nerve endings that are located in the striatum. The severity of PD is proportional to the decline in the amount of dopamine in the striatum. Dopamine is produced from tyrosine, which is first hydroxylated and converted to L-dopa by tyrosine hydroxylase (TH) in the presence of tetrahydrobiopterin (BH4) as a cofactor. Ldopa is subsequently decarboxylated into dopamine by a second enzyme called aromatic L-amino acid decarboxylase (AADC). The BH4 is synthesized from guanosine triphosphate (GTP) in the TH-containing dopamine neurons where GTP cyclohydrolase I (GCH) catalyzes the first and rate limiting step of BH4 biosynthesis. The GCH is considered to regulate the TH activity via regulation of BH4 biosynthesis, and thus controls indirectly dopamine production. More... »

PAGES

459-462

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-0-306-47593-1_78

DOI

http://dx.doi.org/10.1007/978-0-306-47593-1_78

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006176557


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