PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL) View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2015-09-09

AUTHORS

Klaus Okkenhaug , Jan A. Burger

ABSTRACT

B cells provide immunity to extracellular pathogens by secreting a diverse repertoire of antibodies with high affinity and specificity for exposed antigens. The B cell receptor (BCR) is a transmembrane antibody, which facilitates the clonal selection of B cells producing secreted antibodies of the same specificity. The diverse antibody repertoire is generated by V(D)J recombination of heavy and light chain genes, whereas affinity maturation is mediated by activation-induced cytidine deaminase (AID)-mediated mutagenesis. These processes, which are essential for the generation of adaptive humoral immunity, also render B cells susceptible to chromosomal rearrangements and point mutations that in some cases lead to cancer. In this chapter, we will review the central role of PI3K s in mediating signals from the B cell receptor that not only facilitate the development of functional B cell repertoire, but also support the growth and survival of neoplastic B cells, focusing on chronic lymphocytic leukemia (CLL) B cells. Perhaps because of the central role played by PI3K in BCR signaling, B cell leukemia and lymphomas are the first diseases for which a PI3K inhibitor has been approved for clinical use. More... »

PAGES

123-142

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/82_2015_484

DOI

http://dx.doi.org/10.1007/82_2015_484

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035404149

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26350103


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