B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1 View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2011-07-07

AUTHORS

James Hagman , Julita Ramírez , Kara Lukin

ABSTRACT

Early B cell factor 1 (EBF1) is a transcription factor that is critical for both B lymphopoiesis and B cell function. EBF1 is a requisite component of the B lymphocyte transcriptional network and is essential for B lineage specification. Recent studies revealed roles for EBF1 in B cell commitment. EBF1 binds its target genes via a DNA-binding domain including a unique 'zinc knuckle', which mediates a novel mode of DNA recognition. Chromatin immunoprecipitation of EBF1 in pro-B cells defined hundreds of new, as well as previously identified, target genes. Notably, expression of the pre-B cell receptor (pre-BCR), BCR and PI3K/Akt/mTOR signaling pathways is controlled by EBF1. In this review, we highlight these current developments and explore how EBF1 functions as a tissue-specific regulator of chromatin structure at B cell-specific genes. More... »

PAGES

17-38

References to SciGraph publications

  • 1996-10. The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes in NATURE
  • 2004-10. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription in NATURE IMMUNOLOGY
  • 2010-07. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate in NATURE IMMUNOLOGY
  • 1999-10. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 in NATURE
  • 1999-10. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors in NATURE
  • 2008-02. Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5 in NATURE IMMUNOLOGY
  • 1995-07. Failure of B-cell differentiation in mice lacking the transcription factor EBF in NATURE
  • 2010-02. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development in NATURE IMMUNOLOGY
  • 2008-06. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway in NATURE IMMUNOLOGY
  • 2003-03. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals in NATURE GENETICS
  • 2009-10. The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development in NATURE IMMUNOLOGY
  • 1993-07. Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast in NATURE
  • 1996-10. B-cell-specif ic coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation in NATURE
  • 2008-12. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation in NATURE IMMUNOLOGY
  • 2008-08. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros in NATURE IMMUNOLOGY
  • 2007-05. Cell lineage regulators in B and T cell development in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/82_2011_139

    DOI

    http://dx.doi.org/10.1007/82_2011_139

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038517059

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21735360


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "B-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Lineage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphopoiesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Colorado Denver", 
              "id": "https://www.grid.ac/institutes/grid.241116.1", 
              "name": [
                "Integrated Department of Immunology, National Jewish Health and University of Colorado School of Medicine, 80206, Denver, CO, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hagman", 
            "givenName": "James", 
            "id": "sg:person.01117145104.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117145104.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Colorado Denver", 
              "id": "https://www.grid.ac/institutes/grid.241116.1", 
              "name": [
                "Integrated Department of Immunology, National Jewish Health and University of Colorado School of Medicine, 80206, Denver, CO, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ram\u00edrez", 
            "givenName": "Julita", 
            "id": "sg:person.01075437046.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075437046.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Colorado Denver", 
              "id": "https://www.grid.ac/institutes/grid.241116.1", 
              "name": [
                "Integrated Department of Immunology, National Jewish Health and University of Colorado School of Medicine, 80206, Denver, CO, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lukin", 
            "givenName": "Kara", 
            "id": "sg:person.01325402224.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325402224.71"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1084/jem.188.4.699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000675126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.23.6.1946-1960.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002513541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01192-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002528705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.10.17.2198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003116113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-08-236398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003518418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2010.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004151302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/376263a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004320495", 
              "https://doi.org/10.1038/376263a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1191078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004379709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.05.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004543649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.05.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004543649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.21.5.1531-1539.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007766877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20042393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009270462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80507-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009305447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(00)80429-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010318002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.88.9.3982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012000755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.05.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012935976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830201239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013345543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0802550106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013884800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1461", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014012318", 
              "https://doi.org/10.1038/ni1461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1461", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014012318", 
              "https://doi.org/10.1038/ni1461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2010.00933.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014868028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2010.00933.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014868028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015302967", 
              "https://doi.org/10.1038/ng1089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015302967", 
              "https://doi.org/10.1038/ng1089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015625639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015625639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80078-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015652605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2005.07.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017079790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2005.07.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017079790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1616", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017269340", 
              "https://doi.org/10.1038/ni.1616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.288.5470.1439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018033555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0808866106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020312684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.176289", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021177640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2010.00963.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021442566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2010.00963.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021442566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80453-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023618914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molimm.2008.05.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025563929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.194.5.645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026745530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2004.08.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027772674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.12.3.1126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028545309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/383542a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029928727", 
              "https://doi.org/10.1038/383542a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.108.090936", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030293670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.108.090936", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030293670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20050158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030458650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.078519.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031261091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2006.01.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032490130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2006.01.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032490130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.05.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033929167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.05.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033929167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-biochem-010909-095056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034143727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1999.2653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035691467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.7.5.760", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036713175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.88.8.3436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037145373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.08.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037293630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.08.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037293630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037527532", 
              "https://doi.org/10.1038/ni.1787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037527532", 
              "https://doi.org/10.1038/ni.1787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038268281", 
              "https://doi.org/10.1038/ni.1667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1626", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039472745", 
              "https://doi.org/10.1038/ni.1626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdg522", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039525567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1976610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039862982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2008.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040606844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200636642", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040998807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200636642", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040998807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.07.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041371040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.07.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041371040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2007.05.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042139918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c110.150482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042208004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.22.24.8539-8551.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042484683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043582269", 
              "https://doi.org/10.1038/ni1555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1003525107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044227008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.13.6.3392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044336544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/44076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044447708", 
              "https://doi.org/10.1038/44076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/44076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044447708", 
              "https://doi.org/10.1038/44076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.01.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045315686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.01.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045315686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.8.8.970", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047140407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.01.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047204236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90077-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047516589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.23.11.3837-3846.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048537159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049335763", 
              "https://doi.org/10.1038/ni1119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049335763", 
              "https://doi.org/10.1038/ni1119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0809485106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050519889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2007.07.051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050661820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/364121a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050691773", 
              "https://doi.org/10.1038/364121a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1827", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050743912", 
              "https://doi.org/10.1038/ni.1827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.201041137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050970246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-10-055194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051049280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90076-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051102119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/44164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051578606", 
              "https://doi.org/10.1038/44164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/44164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051578606", 
              "https://doi.org/10.1038/44164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/383538a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051681973", 
              "https://doi.org/10.1038/383538a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdg464", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051802400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2010.04.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052375200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.11.11.5756", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052470253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1891", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052943447", 
              "https://doi.org/10.1038/ni.1891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1067518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062445716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/epi.4.8.10108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072302950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.169.1.261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075073833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.180.3.1694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077593522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.181.5.3364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077692814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1991.tb04905.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077836730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1995.tb07290.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082511820"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-07-07", 
        "datePublishedReg": "2011-07-07", 
        "description": "Early B cell factor 1 (EBF1) is a transcription factor that is critical for both B lymphopoiesis and B cell function. EBF1 is a requisite component of the B lymphocyte transcriptional network and is essential for B lineage specification. Recent studies revealed roles for EBF1 in B cell commitment. EBF1 binds its target genes via a DNA-binding domain including a unique 'zinc knuckle', which mediates a novel mode of DNA recognition. Chromatin immunoprecipitation of EBF1 in pro-B cells defined hundreds of new, as well as previously identified, target genes. Notably, expression of the pre-B cell receptor (pre-BCR), BCR and PI3K/Akt/mTOR signaling pathways is controlled by EBF1. In this review, we highlight these current developments and explore how EBF1 functions as a tissue-specific regulator of chromatin structure at B cell-specific genes.", 
        "editor": [
          {
            "familyName": "Murre", 
            "givenName": "Cornelis", 
            "type": "Person"
          }
        ], 
        "genre": "chapter", 
        "id": "sg:pub.10.1007/82_2011_139", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2598886", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2681866", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2456172", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2458592", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2434864", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": {
          "isbn": [
            "978-3-642-24102-4", 
            "978-3-642-24103-1"
          ], 
          "name": "Epigenetic Regulation of Lymphocyte Development", 
          "type": "Book"
        }, 
        "name": "B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1", 
        "pagination": "17-38", 
        "productId": [
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21735360"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1038517059"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/82_2011_139"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b77a88157c3466a036d3052111638726e399395701999f397951ec1fc5fb65d4"
            ]
          }
        ], 
        "publisher": {
          "location": "Berlin, Heidelberg", 
          "name": "Springer Berlin Heidelberg", 
          "type": "Organisation"
        }, 
        "sameAs": [
          "https://doi.org/10.1007/82_2011_139", 
          "https://app.dimensions.ai/details/publication/pub.1038517059"
        ], 
        "sdDataset": "chapters", 
        "sdDatePublished": "2019-04-16T08:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000369_0000000369/records_68978_00000000.jsonl", 
        "type": "Chapter", 
        "url": "https://link.springer.com/10.1007%2F82_2011_139"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/82_2011_139'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/82_2011_139'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/82_2011_139'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/82_2011_139'


     

    This table displays all metadata directly associated to this object as RDF triples.

    396 TRIPLES      23 PREDICATES      120 URIs      28 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/82_2011_139 schema:about N043df5a70dcd48ad889b31b983bb8d01
    2 N21368a3b76c8418d89351d8922ddfd30
    3 N3978157bc49f42958906223995c9352a
    4 N8115808398514a8099fe03efc2bfdacd
    5 N85ed7c706698453595320af34f8f3429
    6 N8e75754c75f24516b4813f41088b4ac3
    7 N9b50cf4fc3cc4f0cad83d7512fad12f1
    8 Nb9ad55170afb4820905a2236afc513a0
    9 anzsrc-for:06
    10 anzsrc-for:0601
    11 schema:author Ndbae5c929c324a88bd88a88ca1e82aaf
    12 schema:citation sg:pub.10.1038/364121a0
    13 sg:pub.10.1038/376263a0
    14 sg:pub.10.1038/383538a0
    15 sg:pub.10.1038/383542a0
    16 sg:pub.10.1038/44076
    17 sg:pub.10.1038/44164
    18 sg:pub.10.1038/ng1089
    19 sg:pub.10.1038/ni.1616
    20 sg:pub.10.1038/ni.1626
    21 sg:pub.10.1038/ni.1667
    22 sg:pub.10.1038/ni.1787
    23 sg:pub.10.1038/ni.1827
    24 sg:pub.10.1038/ni.1891
    25 sg:pub.10.1038/ni1119
    26 sg:pub.10.1038/ni1461
    27 sg:pub.10.1038/ni1555
    28 https://doi.org/10.1002/eji.1830201239
    29 https://doi.org/10.1002/eji.200636642
    30 https://doi.org/10.1002/eji.201041137
    31 https://doi.org/10.1002/j.1460-2075.1991.tb04905.x
    32 https://doi.org/10.1002/j.1460-2075.1995.tb07290.x
    33 https://doi.org/10.1006/jmbi.1999.2653
    34 https://doi.org/10.1016/0092-8674(94)90076-0
    35 https://doi.org/10.1016/0092-8674(94)90077-9
    36 https://doi.org/10.1016/j.cell.2005.02.013
    37 https://doi.org/10.1016/j.cell.2009.08.041
    38 https://doi.org/10.1016/j.coi.2010.02.003
    39 https://doi.org/10.1016/j.devcel.2004.08.006
    40 https://doi.org/10.1016/j.devcel.2008.04.002
    41 https://doi.org/10.1016/j.febslet.2007.07.051
    42 https://doi.org/10.1016/j.immuni.2006.01.012
    43 https://doi.org/10.1016/j.immuni.2007.05.013
    44 https://doi.org/10.1016/j.immuni.2008.05.015
    45 https://doi.org/10.1016/j.immuni.2009.01.012
    46 https://doi.org/10.1016/j.immuni.2009.01.014
    47 https://doi.org/10.1016/j.immuni.2009.07.011
    48 https://doi.org/10.1016/j.immuni.2010.04.013
    49 https://doi.org/10.1016/j.it.2005.07.001
    50 https://doi.org/10.1016/j.molcel.2010.05.004
    51 https://doi.org/10.1016/j.molimm.2008.05.018
    52 https://doi.org/10.1016/j.stem.2010.05.020
    53 https://doi.org/10.1016/s0092-8674(00)80453-5
    54 https://doi.org/10.1016/s1074-7613(00)80078-3
    55 https://doi.org/10.1016/s1074-7613(00)80507-5
    56 https://doi.org/10.1016/s1097-2765(00)80429-3
    57 https://doi.org/10.1073/pnas.0802550106
    58 https://doi.org/10.1073/pnas.0808866106
    59 https://doi.org/10.1073/pnas.0809485106
    60 https://doi.org/10.1073/pnas.1003525107
    61 https://doi.org/10.1073/pnas.88.8.3436
    62 https://doi.org/10.1073/pnas.88.9.3982
    63 https://doi.org/10.1074/jbc.c110.150482
    64 https://doi.org/10.1074/jbc.m110.176289
    65 https://doi.org/10.1084/jem.188.4.699
    66 https://doi.org/10.1084/jem.194.5.645
    67 https://doi.org/10.1084/jem.20042393
    68 https://doi.org/10.1084/jem.20050158
    69 https://doi.org/10.1093/emboj/cdg464
    70 https://doi.org/10.1093/emboj/cdg522
    71 https://doi.org/10.1101/gad.10.17.2198
    72 https://doi.org/10.1101/gad.1976610
    73 https://doi.org/10.1101/gad.7.5.760
    74 https://doi.org/10.1101/gad.8.8.970
    75 https://doi.org/10.1101/gr.078519.108
    76 https://doi.org/10.1111/j.1600-065x.2010.00933.x
    77 https://doi.org/10.1111/j.1600-065x.2010.00963.x
    78 https://doi.org/10.1126/science.1067518
    79 https://doi.org/10.1126/science.1191078
    80 https://doi.org/10.1126/science.288.5470.1439
    81 https://doi.org/10.1128/mcb.01192-06
    82 https://doi.org/10.1128/mcb.11.11.5756
    83 https://doi.org/10.1128/mcb.12.3.1126
    84 https://doi.org/10.1128/mcb.13.6.3392
    85 https://doi.org/10.1128/mcb.21.5.1531-1539.2001
    86 https://doi.org/10.1128/mcb.22.24.8539-8551.2002
    87 https://doi.org/10.1128/mcb.23.11.3837-3846.2003
    88 https://doi.org/10.1128/mcb.23.6.1946-1960.2003
    89 https://doi.org/10.1146/annurev-biochem-010909-095056
    90 https://doi.org/10.1182/blood-2006-10-055194
    91 https://doi.org/10.1182/blood-2009-08-236398
    92 https://doi.org/10.1534/genetics.108.090936
    93 https://doi.org/10.4049/jimmunol.169.1.261
    94 https://doi.org/10.4049/jimmunol.180.3.1694
    95 https://doi.org/10.4049/jimmunol.181.5.3364
    96 https://doi.org/10.4161/epi.4.8.10108
    97 schema:datePublished 2011-07-07
    98 schema:datePublishedReg 2011-07-07
    99 schema:description Early B cell factor 1 (EBF1) is a transcription factor that is critical for both B lymphopoiesis and B cell function. EBF1 is a requisite component of the B lymphocyte transcriptional network and is essential for B lineage specification. Recent studies revealed roles for EBF1 in B cell commitment. EBF1 binds its target genes via a DNA-binding domain including a unique 'zinc knuckle', which mediates a novel mode of DNA recognition. Chromatin immunoprecipitation of EBF1 in pro-B cells defined hundreds of new, as well as previously identified, target genes. Notably, expression of the pre-B cell receptor (pre-BCR), BCR and PI3K/Akt/mTOR signaling pathways is controlled by EBF1. In this review, we highlight these current developments and explore how EBF1 functions as a tissue-specific regulator of chromatin structure at B cell-specific genes.
    100 schema:editor N23bcdcd67a6f48049b03dc9bac2e858b
    101 schema:genre chapter
    102 schema:inLanguage en
    103 schema:isAccessibleForFree true
    104 schema:isPartOf N33efd90ee2934fd6873c3ad984970c1a
    105 schema:name B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1
    106 schema:pagination 17-38
    107 schema:productId N46bbd01a11484575b26a11b54d5a1c59
    108 N52cc5e0317264a02aed55f32aee3784c
    109 Nc9e7e0e6ac6346c8a8682bceb172ebfd
    110 Ncecd1d655b474130b1eb0bbde16931ca
    111 schema:publisher N7a2213e2c1494c95af4f3d8496448813
    112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038517059
    113 https://doi.org/10.1007/82_2011_139
    114 schema:sdDatePublished 2019-04-16T08:59
    115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    116 schema:sdPublisher N3b1ca8015efd450f82475e0040797648
    117 schema:url https://link.springer.com/10.1007%2F82_2011_139
    118 sgo:license sg:explorer/license/
    119 sgo:sdDataset chapters
    120 rdf:type schema:Chapter
    121 N043df5a70dcd48ad889b31b983bb8d01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Epigenesis, Genetic
    123 rdf:type schema:DefinedTerm
    124 N21368a3b76c8418d89351d8922ddfd30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Transcription Factors
    126 rdf:type schema:DefinedTerm
    127 N23bcdcd67a6f48049b03dc9bac2e858b rdf:first Ne7aba81e044f49ec9e542e15349c1684
    128 rdf:rest rdf:nil
    129 N33efd90ee2934fd6873c3ad984970c1a schema:isbn 978-3-642-24102-4
    130 978-3-642-24103-1
    131 schema:name Epigenetic Regulation of Lymphocyte Development
    132 rdf:type schema:Book
    133 N3978157bc49f42958906223995c9352a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Lymphopoiesis
    135 rdf:type schema:DefinedTerm
    136 N3b1ca8015efd450f82475e0040797648 schema:name Springer Nature - SN SciGraph project
    137 rdf:type schema:Organization
    138 N46bbd01a11484575b26a11b54d5a1c59 schema:name pubmed_id
    139 schema:value 21735360
    140 rdf:type schema:PropertyValue
    141 N52cc5e0317264a02aed55f32aee3784c schema:name dimensions_id
    142 schema:value pub.1038517059
    143 rdf:type schema:PropertyValue
    144 N7a2213e2c1494c95af4f3d8496448813 schema:location Berlin, Heidelberg
    145 schema:name Springer Berlin Heidelberg
    146 rdf:type schema:Organisation
    147 N8115808398514a8099fe03efc2bfdacd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Gene Expression Regulation
    149 rdf:type schema:DefinedTerm
    150 N82c9ff06a4c44ae9b710da399ea4eb4d rdf:first sg:person.01325402224.71
    151 rdf:rest rdf:nil
    152 N85ed7c706698453595320af34f8f3429 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name B-Lymphocytes
    154 rdf:type schema:DefinedTerm
    155 N8e75754c75f24516b4813f41088b4ac3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Humans
    157 rdf:type schema:DefinedTerm
    158 N907016874e7c45e79d195aec5a3e3400 rdf:first sg:person.01075437046.92
    159 rdf:rest N82c9ff06a4c44ae9b710da399ea4eb4d
    160 N9b50cf4fc3cc4f0cad83d7512fad12f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Cell Lineage
    162 rdf:type schema:DefinedTerm
    163 Nb9ad55170afb4820905a2236afc513a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Animals
    165 rdf:type schema:DefinedTerm
    166 Nc9e7e0e6ac6346c8a8682bceb172ebfd schema:name readcube_id
    167 schema:value b77a88157c3466a036d3052111638726e399395701999f397951ec1fc5fb65d4
    168 rdf:type schema:PropertyValue
    169 Ncecd1d655b474130b1eb0bbde16931ca schema:name doi
    170 schema:value 10.1007/82_2011_139
    171 rdf:type schema:PropertyValue
    172 Ndbae5c929c324a88bd88a88ca1e82aaf rdf:first sg:person.01117145104.67
    173 rdf:rest N907016874e7c45e79d195aec5a3e3400
    174 Ne7aba81e044f49ec9e542e15349c1684 schema:familyName Murre
    175 schema:givenName Cornelis
    176 rdf:type schema:Person
    177 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    178 schema:name Biological Sciences
    179 rdf:type schema:DefinedTerm
    180 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    181 schema:name Biochemistry and Cell Biology
    182 rdf:type schema:DefinedTerm
    183 sg:grant.2434864 http://pending.schema.org/fundedItem sg:pub.10.1007/82_2011_139
    184 rdf:type schema:MonetaryGrant
    185 sg:grant.2456172 http://pending.schema.org/fundedItem sg:pub.10.1007/82_2011_139
    186 rdf:type schema:MonetaryGrant
    187 sg:grant.2458592 http://pending.schema.org/fundedItem sg:pub.10.1007/82_2011_139
    188 rdf:type schema:MonetaryGrant
    189 sg:grant.2598886 http://pending.schema.org/fundedItem sg:pub.10.1007/82_2011_139
    190 rdf:type schema:MonetaryGrant
    191 sg:grant.2681866 http://pending.schema.org/fundedItem sg:pub.10.1007/82_2011_139
    192 rdf:type schema:MonetaryGrant
    193 sg:person.01075437046.92 schema:affiliation https://www.grid.ac/institutes/grid.241116.1
    194 schema:familyName Ramírez
    195 schema:givenName Julita
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075437046.92
    197 rdf:type schema:Person
    198 sg:person.01117145104.67 schema:affiliation https://www.grid.ac/institutes/grid.241116.1
    199 schema:familyName Hagman
    200 schema:givenName James
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117145104.67
    202 rdf:type schema:Person
    203 sg:person.01325402224.71 schema:affiliation https://www.grid.ac/institutes/grid.241116.1
    204 schema:familyName Lukin
    205 schema:givenName Kara
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325402224.71
    207 rdf:type schema:Person
    208 sg:pub.10.1038/364121a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050691773
    209 https://doi.org/10.1038/364121a0
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/376263a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004320495
    212 https://doi.org/10.1038/376263a0
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/383538a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051681973
    215 https://doi.org/10.1038/383538a0
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/383542a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029928727
    218 https://doi.org/10.1038/383542a0
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/44076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044447708
    221 https://doi.org/10.1038/44076
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/44164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051578606
    224 https://doi.org/10.1038/44164
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/ng1089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015302967
    227 https://doi.org/10.1038/ng1089
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/ni.1616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017269340
    230 https://doi.org/10.1038/ni.1616
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/ni.1626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039472745
    233 https://doi.org/10.1038/ni.1626
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/ni.1667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038268281
    236 https://doi.org/10.1038/ni.1667
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/ni.1787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037527532
    239 https://doi.org/10.1038/ni.1787
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/ni.1827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050743912
    242 https://doi.org/10.1038/ni.1827
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/ni.1891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052943447
    245 https://doi.org/10.1038/ni.1891
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/ni1119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049335763
    248 https://doi.org/10.1038/ni1119
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/ni1461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014012318
    251 https://doi.org/10.1038/ni1461
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/ni1555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043582269
    254 https://doi.org/10.1038/ni1555
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1002/eji.1830201239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013345543
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1002/eji.200636642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040998807
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1002/eji.201041137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050970246
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1002/j.1460-2075.1991.tb04905.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077836730
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1002/j.1460-2075.1995.tb07290.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082511820
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1006/jmbi.1999.2653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035691467
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/0092-8674(94)90076-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051102119
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/0092-8674(94)90077-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047516589
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.cell.2005.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015625639
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.cell.2009.08.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037293630
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.coi.2010.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004151302
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.devcel.2004.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027772674
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.devcel.2008.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040606844
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.febslet.2007.07.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050661820
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.immuni.2006.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032490130
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.immuni.2007.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042139918
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.immuni.2008.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033929167
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.immuni.2009.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045315686
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.immuni.2009.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047204236
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.immuni.2009.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041371040
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.immuni.2010.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052375200
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.it.2005.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017079790
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/j.molcel.2010.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012935976
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/j.molimm.2008.05.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025563929
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/j.stem.2010.05.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004543649
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1016/s0092-8674(00)80453-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023618914
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1016/s1074-7613(00)80078-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015652605
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/s1074-7613(00)80507-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009305447
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/s1097-2765(00)80429-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010318002
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1073/pnas.0802550106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013884800
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1073/pnas.0808866106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020312684
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1073/pnas.0809485106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050519889
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1073/pnas.1003525107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044227008
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1073/pnas.88.8.3436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037145373
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1073/pnas.88.9.3982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012000755
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1074/jbc.c110.150482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042208004
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1074/jbc.m110.176289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021177640
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1084/jem.188.4.699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000675126
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1084/jem.194.5.645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026745530
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1084/jem.20042393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009270462
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1084/jem.20050158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030458650
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1093/emboj/cdg464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051802400
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1093/emboj/cdg522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039525567
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1101/gad.10.17.2198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003116113
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1101/gad.1976610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039862982
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1101/gad.7.5.760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036713175
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1101/gad.8.8.970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047140407
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1101/gr.078519.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031261091
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1111/j.1600-065x.2010.00933.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014868028
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1111/j.1600-065x.2010.00963.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021442566
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1126/science.1067518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445716
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1126/science.1191078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004379709
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1126/science.288.5470.1439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018033555
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1128/mcb.01192-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002528705
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1128/mcb.11.11.5756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052470253
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1128/mcb.12.3.1126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028545309
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1128/mcb.13.6.3392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044336544
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1128/mcb.21.5.1531-1539.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007766877
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1128/mcb.22.24.8539-8551.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042484683
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1128/mcb.23.11.3837-3846.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048537159
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1128/mcb.23.6.1946-1960.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002513541
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1146/annurev-biochem-010909-095056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034143727
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1182/blood-2006-10-055194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051049280
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1182/blood-2009-08-236398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003518418
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1534/genetics.108.090936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030293670
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.4049/jimmunol.169.1.261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075073833
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.4049/jimmunol.180.3.1694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077593522
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.4049/jimmunol.181.5.3364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077692814
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.4161/epi.4.8.10108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072302950
    393 rdf:type schema:CreativeWork
    394 https://www.grid.ac/institutes/grid.241116.1 schema:alternateName University of Colorado Denver
    395 schema:name Integrated Department of Immunology, National Jewish Health and University of Colorado School of Medicine, 80206, Denver, CO, USA
    396 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...