Oncogenic Mutations of PIK3CA in Human Cancers View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2010

AUTHORS

Yardena Samuels , Todd Waldman

ABSTRACT

The involvement of the PIK3CA gene product p110α, the catalytic subunit of phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 years, and support for this proposal had been provided by both genetic and functional studies, including most recently the discovery of common activating missense mutations of PIK3CA in a wide variety of common human tumor types. This chapter will focus on the discovery of these mutations and describes their relevance to a wide range of common human tumor types.Of note, the identification and functional analysis of the PIK3CA gene are reviewed in other chapters in this book. However, a brief mention will be made here of its general properties as background to our focus on the discovery of its cancer-specific mutations. More... »

PAGES

21-41

References to SciGraph publications

  • 2006-03. PIK3CA mutations in breast cancer are associated with poor outcome in BREAST CANCER RESEARCH AND TREATMENT
  • 2006-03. Automating sequence-based detection and genotyping of SNPs from diploid samples in NATURE GENETICS
  • 2009-09. PIK3CA mutation occurs in nasopharyngeal carcinoma but does not significantly influence the disease-specific survival in MEDICAL ONCOLOGY
  • 1987-05. Prevalence of ras gene mutations in human colorectal cancers in NATURE
  • 2002-06. Mutations of the BRAF gene in human cancer in NATURE
  • 2008-08. Exon 20 PIK3CA mutations decreases survival in aggressive (HER-2 positive) breast carcinomas in VIRCHOWS ARCHIV
  • 2006-03. Rare mutation of PIK3CA in meningiomas in ACTA NEUROPATHOLOGICA
  • 2007-03. Epidermal growth factor receptor mutations in lung cancer in NATURE REVIEWS CANCER
  • 2002-08. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status in NATURE
  • 1998-07. Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines in ONCOGENE
  • 1999-01. PIK3CA is implicated as an oncogene in ovarian cancer in NATURE GENETICS
  • 2005-08. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis in NATURE
  • 2007-03. PIK3CA alterations in primary (de novo) and secondary glioblastomas in ACTA NEUROPATHOLOGICA
  • 2005-06. PIK3CA mutations in glioblastoma multiforme in ACTA NEUROPATHOLOGICA
  • 2005-12. Mutations of PIK3CAin gastric adenocarcinoma in BMC CANCER
  • 2005-08. Colorectal cancer: Mutations in a signalling pathway in NATURE
  • 2005-10. Somatic mutation and gain of copy number of PIK3CA in human breast cancer in BREAST CANCER RESEARCH
  • 1997-04. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers in NATURE GENETICS
  • 2006-12. Mutations in PIK3CAare infrequent in neuroblastoma in BMC CANCER
  • 2007-11. PIK3CA mutations are mutually exclusive with PTEN loss in diffuse large B-cell lymphoma in LEUKEMIA
  • 2008-06. Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population in ONCOGENE
  • 2000-05. PIK3CA as an oncogene in cervical cancer in ONCOGENE
  • 2008-04. PIK3CA Exon 20 Mutation is Independently Associated with a Poor Prognosis in Breast Cancer Patients in ANNALS OF SURGICAL ONCOLOGY
  • 2000-02. Mutation and Allelic Loss of the PTEN/MMAC1 gene in Primary and Metastatic Melanoma Biopsies in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1993-02. Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma in NATURE GENETICS
  • 2007-07. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer in NATURE
  • 2008-04. PIK3CA-activating mutations and chemotherapy sensitivity in stage II–III breast cancer in BREAST CANCER RESEARCH
  • 2005-02. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas in ONCOGENE
  • 2008-10-23. Comprehensive genomic characterization defines human glioblastoma genes and core pathways in NATURE
  • 2008-02. PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters in MODERN PATHOLOGY
  • 2008-09. AKT1E17K in human solid tumours in ONCOGENE
  • 2005-06. Mutations of the PIK3CA gene are rare in human glioblastoma in ACTA NEUROPATHOLOGICA
  • 2006-05. Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients in ONCOGENE
  • 2002-07. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer in NATURE REVIEWS CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/82_2010_68

    DOI

    http://dx.doi.org/10.1007/82_2010_68

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000260532

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20535651


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