Oxytocin and Steroid Actions View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017-08-16

AUTHORS

Gustav F. Jirikowski , Scott D. Ochs , Jack D. Caldwell

ABSTRACT

Biosynthesis and secretion of the hypothalamic nonapeptide oxytocin largely depends on steroid hormones. Estradiol, corticosterone, and vitamin D seem to be the most prominent actors. Due to their lipophilic nature, systemic steroids are thought to be capable of crossing the blood–brain barrier, thus mediating central functions including neuroendocrine and behavioral control. The actual mode of action of steroids in hypothalamic circuitry is still unknown: Most of the oxytocinergic perikarya lack nuclear steroid receptors but express proteins suspected to be membrane receptors for steroids. Oxytocin expressing neurons contain enzymes important for intrinsic steroid metabolism. Furthermore, they produce and probably liberate specific steroid-binding globulins. Rapid responses to steroid hormones may involve these binding proteins and membrane-associated receptors, rather than classic nuclear receptors and genomic pathways. Neuroendocrine regulation, reproductive behaviors, and stress response seem to depend on these mechanisms. More... »

PAGES

77-95

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/7854_2017_9

DOI

http://dx.doi.org/10.1007/7854_2017_9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091217376

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28812264


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