Effect of Bone Marrow Transplantation in Patients with Critical Limb Ischemia View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2005

AUTHORS

Yousuke Katsuda , Yoshiaki Takeshita , Ken Arima , Yutaka Saitoh , Ken-ichiro Sasaki , Shinichi Shintani , Toyoaki Murohara , Tsutomu Imaizumi

ABSTRACT

Background: Endothelial progenitor cells in the CD34+ stem-cell fraction of adult human peripheral blood take a part in postnatal neovascularization after mobilization from bone marrow. We investigated whether transplantation of bone marrow-mononuclear cells (BM-MNCs), including endothelial progenitor cells (EPCs), into ischemic limbs rescues ischemia in patients with peripheral artery occulusive disease (PAOD). Methods and Results: 22 patients with severe PAOD (atherosclerosis obliterance and Thromboangiitis obliterance / Burger’s disease) were enrolled. After collecting MNCs from the autologous bone marrow using the density gradient centrifugation method, we transplanted them into the ischemic limb. Four weeks after transplantation, pain quantified by the Visual Analog Scale was significantly improved. Skin ulcers healed in 6 of 10 patients and the size was reduced in the rest of them. Ankle brachial blood pressure ratio index (ABI) increased (0.58 ±0.2 to 0.69±0.26 at 4weeks). Furthermore, most of patients revealed angiographical improvements. No adverse event was observed. Conclusion: Our findings indicate that therapeutic angiogenesis by transplantation of autologous BM-MNCs is effective and safe for patients with PAOD. More... »

PAGES

213-220

Book

TITLE

Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches

ISBN

4-431-23925-1

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/4-431-27378-6_18

DOI

http://dx.doi.org/10.1007/4-431-27378-6_18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014222034


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