Role of pericytes in vascular morphogenesis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2005

AUTHORS

Christer Betsholtz , Per Lindblom , Holger Gerhardt

ABSTRACT

Pericytes are solitary, smooth muscle-like mural cells that invest the wall of microvessels. For a long time, the functional significance of the presence and distribution of pericytes in the microvasculature was unclear. However, in recent years, the application of experimental genetics to the PDGF-B/PDGFRbeta signaling pathway in mice has provided a range of mutants with primary defects in pericytes, allowing for studies of the physiological consequences of pericyte deficiency in developmental angiogenesis and adult physiology. Interestingly, some of the phenotypic consequences of these mutations resemble human diseases, such as diabetic retinopathy. The studies have also led to the discovery of critical mechanisms involved in pericyte recruitment and differentiation. The present review focuses on genetic data suggesting that pericytes take active part in developmental angiogenic processes. More... »

PAGES

115-125

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/3-7643-7311-3_8

DOI

http://dx.doi.org/10.1007/3-7643-7311-3_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001167616

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15617474


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