Transition and main-group metal cyclopentadienyl complexes: Preclinical studies on a series of antitumor agents of different structural type View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

Petra Köpf-Maier , Hartmut Köpf

ABSTRACT

Cyclopentadienyl metal complexes are organometallic compounds which exhibit antiproliferative properties in vivo and in vitro. They are represented by compounds of various structural type. The metallocene diacido complexes (C5H5)2MX2 contain early transition metal atoms such as titanium(IV) and vanadium(IV), the ionic metallicenium salts [(C5H5)2M]+X− include medium transition metals, e.g. iron(III), whereas the uncharged decasubstituted metallocenes (C5R5)2M comprise the main group elements tin(II) and germanium(II) as central metal atoms M. A variety of biological data are available about metallocene diacido complexes, especially titanocene dichloride. These substances exhibit antitumor properties against numerous experimental tumors, e.g. Ehrlich ascites tumor, B 16 melanoma, colon 38 carcinoma, Lewis lung carcinoma, as well as against various human tumors heterotransplanted to athymic mice. Biological experiments using (C5H5)2TiCl2 and (C5H5)2VCl2 pointed to the nucleic acids as a probable target for metallocene diacido complexes within the cells, revealed a main accumulation of titanium or vanadium in the liver and the intestine and unfolded a pattern of organ toxicity which fundamentally differs from that of other cytostatic drugs. These biological features confirm the cyclopentadienyl metal complexes to be an independent group of non-platinum-group metal antitumor agents being characterized by unusual biological properties. They represent interesting candidates for future biological and clinical investigations. More... »

PAGES

103-185

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/3-540-50130-4_3

DOI

http://dx.doi.org/10.1007/3-540-50130-4_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035090550


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