Functional genetics of Yarrowia lipolytica View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2003-07-10

AUTHORS

Gerold Barth , Jean-Marie Beckerich , Angel Dominguez , Stefan Kerscher , David Ogrydziak , Vladimir Titorenko , Claude Gaillardin

ABSTRACT

The yeast Yarrowia lipolytica has been used for industrial bioconversions since the late 1960’s, mainly by the food and chemical industries. The most important process is presently the production of citric acid from rapeseed oil, but Y. lipolytica has also been considered for various other applications, ranging from single cell protein to heterologous proteins production. Several of these procedures have received a GRAS status, which facilitates further applications of this yeast in the food and pharmaceutical industries. This review focuses on the acquisition of basic knowledge on Y. lipolytica, which is physiologically and taxonomically very distant from Saccharomyces cerevisiae. Thanks to the development of advanced genetic tools for both classical approaches and recombinant DNA technology, significant progresses have been achieved in several aspects of its unusual biology. Particular attention has been paid to the study of early steps of protein secretion, peroxisome biogenesis, carbon metabolism and utilisation of hydrophobic substrates, mitochondrial biology, morphogenetic control, and proteae regulation. An international effort relayed by the Genoscope will permit access to its full genome sequence by the end of 2003, thus facilitating further developments of its functional genetics. More... »

PAGES

227-271

Book

TITLE

Functional Genetics of Industrial Yeasts

ISBN

978-3-540-02489-7
978-3-540-37003-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/3-540-37003-x_8

DOI

http://dx.doi.org/10.1007/3-540-37003-x_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005091603


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