Rotavirus Genome Replication and Morphogenesis: Role of the Viroplasm View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2006

AUTHORS

J. T. Patton , L. S. Silvestri , M. A. Tortorici , R. Vasquez-Del Carpio , Z. F. Taraporewala

ABSTRACT

The rotaviruses, members of the family Reoviridae, are icosahedral triple-layered viruses with genomes consisting of 11 segments of double-stranded (ds)RNA. A characteristic feature of rotavirus-infected cells is the formation of large cytoplasmic inclusion bodies, termed viroplasms. These dynamic and highly organized structures serve as viral factories that direct the packaging and replication of the viral genome into early capsid assembly intermediates. Migration of the intermediates to the endoplasmic reticulum (ER) initiates a budding process that culminates in final capsid assembly. Recent information on the development and organization of viroplasms, the structure and function of its components, and interactive pathways linking RNA synthesis and capsid assembly provide new insight into how these microenvironments serve to interface the replication and morphogenetic processes of the virus. More... »

PAGES

169-187

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/3-540-30773-7_6

DOI

http://dx.doi.org/10.1007/3-540-30773-7_6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042361912

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16909900


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