A novel neuroprotective compound FR901459 with dual inhibition of calcineurin and cyclophilins View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2006

AUTHORS

H. Uchino , S. Morota , T. Takahashi , Y. Ikeda , Y. Kudo , N. Ishii , B. K. Siesjö , F. Shibasaki

ABSTRACT

Brain ischemia leads to severe damage in the form of delayed neuronal cell death. In our study, we show that the marked neuroprotection of the new immunosuppressant FR901495 in forebrain ischemia is due not only to inhibition of calcineurin, but also to protection against mitochondrial damage caused by mitochondrial permeability transition pore formation through cyclophilin D, one of the prolyl cis/trans isomerase family members. These findings shed light on the clinical application and development of new drugs for the treatment of ischemic damage in the brain as well as in the heart and liver. More... »

PAGES

157-62

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/3-211-30714-1_35

DOI

http://dx.doi.org/10.1007/3-211-30714-1_35

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030304160

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16671446


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