Hearing Loss, Protection, and Regeneration in the Larval Zebrafish Lateral Line View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013-08-23

AUTHORS

Allison B. Coffin , Heather Brignull , David W. Raible , Edwin W. Rubel

ABSTRACT

This chapter reviews how the larval zebrafish lateral line serves as a model system for studying hair cell death and regeneration. Drugs or vital dyes are rapidly taken up by lateral line hair cells and their effects can be quickly determined by visual assessment. Studies characterizing the death and robust regeneration of lateral line hair cells after exposure to a range of known toxins have established the lateral line as an in vivo model system for understanding these processes. The lateral line has also been the focus of several large-scale drug screens designed to identify novel ototoxins, protective compounds, and compounds that modulate hair cell regeneration. Genetic screens have also provided data about the genes contributing to toxin sensitivity and hair cell regeneration. The combination of rapid, quantitative assays with methods for in vivo visualization make the zebrafish lateral line a promising system for understanding fundamental processes underlying hair cell death and regeneration, and for identifying potential fruitful approaches to modulating these processes in other systems. More... »

PAGES

313-347

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/2506_2013_20

DOI

http://dx.doi.org/10.1007/2506_2013_20

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023642532


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