Molecular-Scale Studies on Biopolymers Using Atomic Force Microscopy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2006

AUTHORS

James S. Ellis , Stephanie Allen , Ya Tsz A. Chim , Clive J. Roberts , Saul J. B. Tendler , Martyn C. Davies

ABSTRACT

The atomic force microscope (AFM) is capable of acquiring a range of structural and physicochemical information on a wide range of biopolymers. The ability to achieve nanoscale resolution, coupled with the potential to image and manipulate real-time molecular-scale events, suggests that AFM is one of the most promising techniques available for the study of biopolymers. AFM offers the potential to obtain a wide range of both quantitative and qualitative information on biopolymers, ranging from their conformations in physiological buffers to the forces involved in bond cleavage. This review explores the most common modes of AFM operation including imaging (contact and tapping mode) and force spectroscopy. The application of these modes to biopolymer characterisation will be discussed, with an emphasis on key studies. More... »

PAGES

123-172

Book

TITLE

Polymer Therapeutics II

ISBN

3-540-29211-X

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/12_027

DOI

http://dx.doi.org/10.1007/12_027

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008708090


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