Mesenchymal Stem Cells as Cellular Immunotherapeutics in Allogeneic Hematopoietic Stem Cell Transplantation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Claudia Papewalis , Daniela Topolar , Barbara Götz , Stefan Schönberger , Dagmar Dilloo

ABSTRACT

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment option in hematopoietic disorders, immunodeficiencies and leukemia. To date graft-versus-host disease (GvHD) represents a life-threatening complication even if associated with beneficial antileukemic reactivity. GvHD is the clinical manifestation of donor cells reacting against host tissue. Because of their ability to facilitate endogenous repair and to attenuate inflammation, MSC have evolved as a highly attractive cellular therapeutic in allo-HSCT. Here we report on the clinical experience in the use of MSC to enhance engraftment and prevent and treat acute and chronic GvHD. In early clinical trials, MSC have shown considerable benefit in the setting of manifest GvHD. These encouraging results warrant further exploration. More... »

PAGES

131-62

References to SciGraph publications

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  • Book

    TITLE

    Mesenchymal Stem Cells - Basics and Clinical Application II

    ISBN

    978-3-642-37943-7
    978-3-642-37944-4

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/10_2012_158

    DOI

    http://dx.doi.org/10.1007/10_2012_158

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009681974

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23455489


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