Bone Metastasis Microenvironment Participates in the Development of Androgen Ablation Refractoriness and Chemotherapy Resistance of Prostate Cancer Cells Residing in ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2005

AUTHORS

M. Koutsilieris , R. Tenta , D. Tiblalexi , N. Pitulis , E. Sotiriou , P. Lembessis , J. Bogdanos , C. Milathianakis , A. Sourla

ABSTRACT

The development of resistance to anti-cancer therapies is a major hurdle preventing long-lasting clinical responses to conventional or investigational therapies in hormone refractory prostate cancer. Herein, we analyze the molecular evidence which show that bone metastasis microenvironment survival factors, mainly paracrine, growth hormone (GH)-independent, urokinase-type plasminogen activator (uPA)-mediated production of insulin-like growth factor 1 (IGF-1) and endocrine, GH-dependent production of IGF-1 (mainly liver-derived IGF-1), produce an epigenetic form of cancer cells resistance to pro-apoptotic therapies. In addition, we review the conceptual framework of a novel hormone manipulation for hormone refractory metastatic prostate cancer (combination of dexamethasone and somatostatin analog (SM-A)), which yielded durable objective responses and major improvement of bone pain and performance status in stage D3 prostate cancer patients. More... »

PAGES

335-344

Book

TITLE

Integration/Interaction of Oncologic Growth

ISBN

1-4020-3413-X

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/1-4020-3414-8_19

DOI

http://dx.doi.org/10.1007/1-4020-3414-8_19

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001246451


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, Goudi-Athens, 115 27, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koutsilieris", 
        "givenName": "M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, Goudi-Athens, 115 27, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tenta", 
        "givenName": "R.", 
        "id": "sg:person.01125531320.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125531320.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, Goudi-Athens, 115 27, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tiblalexi", 
        "givenName": "D.", 
        "id": "sg:person.01173644520.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173644520.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, Goudi-Athens, 115 27, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pitulis", 
        "givenName": "N.", 
        "id": "sg:person.01201457755.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201457755.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, Goudi-Athens, 115 27, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sotiriou", 
        "givenName": "E.", 
        "id": "sg:person.0750632422.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750632422.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, Goudi-Athens, 115 27, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lembessis", 
        "givenName": "P.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, Goudi-Athens, 115 27, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bogdanos", 
        "givenName": "J.", 
        "id": "sg:person.01142335221.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142335221.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, Goudi-Athens, 115 27, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milathianakis", 
        "givenName": "C.", 
        "id": "sg:person.01210450421.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210450421.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, Goudi-Athens, 115 27, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sourla", 
        "givenName": "A.", 
        "id": "sg:person.0750525645.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750525645.03"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/cncr.11136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003123611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-4295(98)00182-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003279232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2001.1804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003601096", 
          "https://doi.org/10.1054/bjoc.2001.1804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19860815)58:4<949::aid-cncr2820580424>3.0.co;2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003826397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.10233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004039800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.10370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004084844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.10349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005424138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00665959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007810013", 
          "https://doi.org/10.1007/bf00665959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00665959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007810013", 
          "https://doi.org/10.1007/bf00665959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1993.1506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008709902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0045(19990601)39:4<246::aid-pros5>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012163909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/13543784.10.6.1099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012312469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-4295(01)01405-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013051979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.2990090202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013103058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4644(19960401)61:1<18::aid-jcb3>3.0.co;2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013942496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016286671", 
          "https://doi.org/10.1038/nrc867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016286671", 
          "https://doi.org/10.1038/nrc867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.2990270508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020573125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.2003.18.2.190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020641054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/13543784.11.2.283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021919522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1532-5415.2003.51367.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022331769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1025860214891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022506022", 
          "https://doi.org/10.1023/a:1025860214891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4419-9129-4_9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022910385", 
          "https://doi.org/10.1007/978-1-4419-9129-4_9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.14.7263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025701476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002512-200320090-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026094172", 
          "https://doi.org/10.2165/00002512-200320090-00005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002512-200320090-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026094172", 
          "https://doi.org/10.2165/00002512-200320090-00005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0033-8389(05)70153-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028078731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0033-8389(05)70153-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028078731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19880101)61:1<195::aid-cncr2820610133>3.0.co;2-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028158765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m308158200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034818392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0045(19990515)39:3<187::aid-pros7>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034964028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4419-9129-4_11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035857135", 
          "https://doi.org/10.1007/978-1-4419-9129-4_11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.1.4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036789218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m304494200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037862682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/95.6.458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038366969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.blo.0000093047.96273.4e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038708593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.blo.0000093047.96273.4e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038708593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19971015)80:8+<1581::aid-cncr8>3.0.co;2-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039638941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0045(19990301)38:4<313::aid-pros7>3.0.co;2-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041487749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.10231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041917571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.10363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042270951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19971015)80:8+<1546::aid-cncr4>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042904616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.10788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043974477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19890601)63:11<2234::aid-cncr2820631130>3.0.co;2-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045013388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0045(19980615)36:1<14::aid-pros3>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045707108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.20030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045794958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci11685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046571956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.urology.2003.08.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046698092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0305-7372(03)00071-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048240448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0305-7372(03)00071-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048240448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/vxkk-yvrh-9b11-ydpt", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048953330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.1.17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049172180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049796132", 
          "https://doi.org/10.1038/sj.cgt.7700665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049796132", 
          "https://doi.org/10.1038/sj.cgt.7700665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc.0.0100279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050383095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc.0.0100279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050383095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci113186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050756254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-4295(79)90280-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051532165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-4295(02)01589-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053503373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-4295(02)01589-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053503373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.20.3.833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1064243169", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.86.12.8119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064324084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1389450033346830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069180091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.5.6.1389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071535802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074508230", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03401935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074687025", 
          "https://doi.org/10.1007/bf03401935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074714403", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075055239", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075104066", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075208230", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03402030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075215478", 
          "https://doi.org/10.1007/bf03402030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075250668", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075314244", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077297637", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080629822", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082680495", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082841361", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083100669", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005", 
    "datePublishedReg": "2005-01-01", 
    "description": "The development of resistance to anti-cancer therapies is a major hurdle preventing long-lasting clinical responses to conventional or investigational therapies in hormone refractory prostate cancer. Herein, we analyze the molecular evidence which show that bone metastasis microenvironment survival factors, mainly paracrine, growth hormone (GH)-independent, urokinase-type plasminogen activator (uPA)-mediated production of insulin-like growth factor 1 (IGF-1) and endocrine, GH-dependent production of IGF-1 (mainly liver-derived IGF-1), produce an epigenetic form of cancer cells resistance to pro-apoptotic therapies. In addition, we review the conceptual framework of a novel hormone manipulation for hormone refractory metastatic prostate cancer (combination of dexamethasone and somatostatin analog (SM-A)), which yielded durable objective responses and major improvement of bone pain and performance status in stage D3 prostate cancer patients.", 
    "editor": [
      {
        "familyName": "Meadows", 
        "givenName": "Gary G.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/1-4020-3414-8_19", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "1-4020-3413-X"
      ], 
      "name": "Integration/Interaction of Oncologic Growth", 
      "type": "Book"
    }, 
    "name": "Bone Metastasis Microenvironment Participates in the Development of Androgen Ablation Refractoriness and Chemotherapy Resistance of Prostate Cancer Cells Residing in the Skeleton: Clinical Implications", 
    "pagination": "335-344", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/1-4020-3414-8_19"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "05efd7b05d96b630bb081f4c5151cad85a91b984adedbbe809616baa47ce50d1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001246451"
        ]
      }
    ], 
    "publisher": {
      "location": "Berlin/Heidelberg", 
      "name": "Springer-Verlag", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/1-4020-3414-8_19", 
      "https://app.dimensions.ai/details/publication/pub.1001246451"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T16:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000243.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/1-4020-3414-8_19"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/1-4020-3414-8_19'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/1-4020-3414-8_19'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/1-4020-3414-8_19'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/1-4020-3414-8_19'


 

This table displays all metadata directly associated to this object as RDF triples.

325 TRIPLES      23 PREDICATES      97 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/1-4020-3414-8_19 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N46fd4c06cc4045618889afba000ec0f5
4 schema:citation sg:pub.10.1007/978-1-4419-9129-4_11
5 sg:pub.10.1007/978-1-4419-9129-4_9
6 sg:pub.10.1007/bf00665959
7 sg:pub.10.1007/bf03401935
8 sg:pub.10.1007/bf03402030
9 sg:pub.10.1023/a:1025860214891
10 sg:pub.10.1038/nrc867
11 sg:pub.10.1038/sj.cgt.7700665
12 sg:pub.10.1054/bjoc.2001.1804
13 sg:pub.10.2165/00002512-200320090-00005
14 https://app.dimensions.ai/details/publication/pub.1064243169
15 https://app.dimensions.ai/details/publication/pub.1074508230
16 https://app.dimensions.ai/details/publication/pub.1074714403
17 https://app.dimensions.ai/details/publication/pub.1075055239
18 https://app.dimensions.ai/details/publication/pub.1075104066
19 https://app.dimensions.ai/details/publication/pub.1075208230
20 https://app.dimensions.ai/details/publication/pub.1075250668
21 https://app.dimensions.ai/details/publication/pub.1075314244
22 https://app.dimensions.ai/details/publication/pub.1077297637
23 https://app.dimensions.ai/details/publication/pub.1080629822
24 https://app.dimensions.ai/details/publication/pub.1082680495
25 https://app.dimensions.ai/details/publication/pub.1082841361
26 https://app.dimensions.ai/details/publication/pub.1083100669
27 https://doi.org/10.1002/(sici)1097-0045(19980615)36:1<14::aid-pros3>3.0.co;2-b
28 https://doi.org/10.1002/(sici)1097-0045(19990301)38:4<313::aid-pros7>3.0.co;2-8
29 https://doi.org/10.1002/(sici)1097-0045(19990515)39:3<187::aid-pros7>3.0.co;2-3
30 https://doi.org/10.1002/(sici)1097-0045(19990601)39:4<246::aid-pros5>3.0.co;2-u
31 https://doi.org/10.1002/(sici)1097-0142(19971015)80:8+<1546::aid-cncr4>3.0.co;2-i
32 https://doi.org/10.1002/(sici)1097-0142(19971015)80:8+<1581::aid-cncr8>3.0.co;2-n
33 https://doi.org/10.1002/(sici)1097-4644(19960401)61:1<18::aid-jcb3>3.0.co;2-5
34 https://doi.org/10.1002/1097-0142(19860815)58:4<949::aid-cncr2820580424>3.0.co;2-5
35 https://doi.org/10.1002/1097-0142(19880101)61:1<195::aid-cncr2820610133>3.0.co;2-y
36 https://doi.org/10.1002/1097-0142(19890601)63:11<2234::aid-cncr2820631130>3.0.co;2-t
37 https://doi.org/10.1002/cncr.10788
38 https://doi.org/10.1002/cncr.11136
39 https://doi.org/10.1002/pros.10231
40 https://doi.org/10.1002/pros.10233
41 https://doi.org/10.1002/pros.10349
42 https://doi.org/10.1002/pros.10363
43 https://doi.org/10.1002/pros.10370
44 https://doi.org/10.1002/pros.20030
45 https://doi.org/10.1002/pros.2990090202
46 https://doi.org/10.1002/pros.2990270508
47 https://doi.org/10.1006/bbrc.1993.1506
48 https://doi.org/10.1016/0090-4295(79)90280-2
49 https://doi.org/10.1016/j.urology.2003.08.041
50 https://doi.org/10.1016/s0033-8389(05)70153-6
51 https://doi.org/10.1016/s0090-4295(01)01405-4
52 https://doi.org/10.1016/s0090-4295(02)01589-3
53 https://doi.org/10.1016/s0090-4295(98)00182-4
54 https://doi.org/10.1016/s0305-7372(03)00071-9
55 https://doi.org/10.1046/j.1532-5415.2003.51367.x
56 https://doi.org/10.1073/pnas.93.14.7263
57 https://doi.org/10.1074/jbc.m304494200
58 https://doi.org/10.1074/jbc.m308158200
59 https://doi.org/10.1093/jnci/94.1.17
60 https://doi.org/10.1093/jnci/94.1.4
61 https://doi.org/10.1093/jnci/95.6.458
62 https://doi.org/10.1097/01.blo.0000093047.96273.4e
63 https://doi.org/10.1172/jci113186
64 https://doi.org/10.1172/jci11685
65 https://doi.org/10.1200/jco.20.3.833
66 https://doi.org/10.1210/jcem.86.12.8119
67 https://doi.org/10.1309/vxkk-yvrh-9b11-ydpt
68 https://doi.org/10.1359/jbmr.2003.18.2.190
69 https://doi.org/10.1517/13543784.10.6.1099
70 https://doi.org/10.1517/13543784.11.2.283
71 https://doi.org/10.1677/erc.0.0100279
72 https://doi.org/10.2174/1389450033346830
73 https://doi.org/10.3892/or.5.6.1389
74 schema:datePublished 2005
75 schema:datePublishedReg 2005-01-01
76 schema:description The development of resistance to anti-cancer therapies is a major hurdle preventing long-lasting clinical responses to conventional or investigational therapies in hormone refractory prostate cancer. Herein, we analyze the molecular evidence which show that bone metastasis microenvironment survival factors, mainly paracrine, growth hormone (GH)-independent, urokinase-type plasminogen activator (uPA)-mediated production of insulin-like growth factor 1 (IGF-1) and endocrine, GH-dependent production of IGF-1 (mainly liver-derived IGF-1), produce an epigenetic form of cancer cells resistance to pro-apoptotic therapies. In addition, we review the conceptual framework of a novel hormone manipulation for hormone refractory metastatic prostate cancer (combination of dexamethasone and somatostatin analog (SM-A)), which yielded durable objective responses and major improvement of bone pain and performance status in stage D3 prostate cancer patients.
77 schema:editor N6d68dd80626d4ff1ac46a67ba07fa209
78 schema:genre chapter
79 schema:inLanguage en
80 schema:isAccessibleForFree false
81 schema:isPartOf N2267b7e6cfb5409e9e3a3d85f55df175
82 schema:name Bone Metastasis Microenvironment Participates in the Development of Androgen Ablation Refractoriness and Chemotherapy Resistance of Prostate Cancer Cells Residing in the Skeleton: Clinical Implications
83 schema:pagination 335-344
84 schema:productId N1032578507ab448ca83a6a7858b9798f
85 N3b17bb34dfda4d778dc11f2e3bbd3ebc
86 N4456a0551f9b45e2938d7f06c09a1678
87 schema:publisher Nc2a045b322f3411cb2e01352f26a8c95
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001246451
89 https://doi.org/10.1007/1-4020-3414-8_19
90 schema:sdDatePublished 2019-04-15T16:13
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher Nf74ef916cc954d64adcbf64134885428
93 schema:url http://link.springer.com/10.1007/1-4020-3414-8_19
94 sgo:license sg:explorer/license/
95 sgo:sdDataset chapters
96 rdf:type schema:Chapter
97 N033680671c3841beacd923ae46079c73 rdf:first N306f74fce7154bb9ab89a17fd2588e61
98 rdf:rest Nbb73028b3a234bac9b1ae9709cf3e110
99 N03e6ce2dfd0f497bb2a39fb479b3d404 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
100 schema:familyName Koutsilieris
101 schema:givenName M.
102 rdf:type schema:Person
103 N1032578507ab448ca83a6a7858b9798f schema:name readcube_id
104 schema:value 05efd7b05d96b630bb081f4c5151cad85a91b984adedbbe809616baa47ce50d1
105 rdf:type schema:PropertyValue
106 N2267b7e6cfb5409e9e3a3d85f55df175 schema:isbn 1-4020-3413-X
107 schema:name Integration/Interaction of Oncologic Growth
108 rdf:type schema:Book
109 N306f74fce7154bb9ab89a17fd2588e61 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
110 schema:familyName Lembessis
111 schema:givenName P.
112 rdf:type schema:Person
113 N30ccc6b8902d4fc69ebdad84b4799676 rdf:first sg:person.01201457755.05
114 rdf:rest N3a4906cd3df64aa99b6950d38664a18d
115 N36138200cf35476a9d8c2cce2df591b5 rdf:first sg:person.01173644520.70
116 rdf:rest N30ccc6b8902d4fc69ebdad84b4799676
117 N3a4906cd3df64aa99b6950d38664a18d rdf:first sg:person.0750632422.73
118 rdf:rest N033680671c3841beacd923ae46079c73
119 N3b17bb34dfda4d778dc11f2e3bbd3ebc schema:name doi
120 schema:value 10.1007/1-4020-3414-8_19
121 rdf:type schema:PropertyValue
122 N4456a0551f9b45e2938d7f06c09a1678 schema:name dimensions_id
123 schema:value pub.1001246451
124 rdf:type schema:PropertyValue
125 N46fd4c06cc4045618889afba000ec0f5 rdf:first N03e6ce2dfd0f497bb2a39fb479b3d404
126 rdf:rest N97f9d88c6c5d441ab5b219eba4574f94
127 N6d68dd80626d4ff1ac46a67ba07fa209 rdf:first N6ffe94568f7e4d94ae2db860bf936b03
128 rdf:rest rdf:nil
129 N6ffe94568f7e4d94ae2db860bf936b03 schema:familyName Meadows
130 schema:givenName Gary G.
131 rdf:type schema:Person
132 N84f361a31adc43c4b0aa102a1ce1215b rdf:first sg:person.01210450421.25
133 rdf:rest Nf2e3b65f00734e678243518ddcbdd7ce
134 N97f9d88c6c5d441ab5b219eba4574f94 rdf:first sg:person.01125531320.59
135 rdf:rest N36138200cf35476a9d8c2cce2df591b5
136 Nbb73028b3a234bac9b1ae9709cf3e110 rdf:first sg:person.01142335221.83
137 rdf:rest N84f361a31adc43c4b0aa102a1ce1215b
138 Nc2a045b322f3411cb2e01352f26a8c95 schema:location Berlin/Heidelberg
139 schema:name Springer-Verlag
140 rdf:type schema:Organisation
141 Nf2e3b65f00734e678243518ddcbdd7ce rdf:first sg:person.0750525645.03
142 rdf:rest rdf:nil
143 Nf74ef916cc954d64adcbf64134885428 schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
146 schema:name Medical and Health Sciences
147 rdf:type schema:DefinedTerm
148 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
149 schema:name Clinical Sciences
150 rdf:type schema:DefinedTerm
151 sg:person.01125531320.59 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
152 schema:familyName Tenta
153 schema:givenName R.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125531320.59
155 rdf:type schema:Person
156 sg:person.01142335221.83 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
157 schema:familyName Bogdanos
158 schema:givenName J.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142335221.83
160 rdf:type schema:Person
161 sg:person.01173644520.70 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
162 schema:familyName Tiblalexi
163 schema:givenName D.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173644520.70
165 rdf:type schema:Person
166 sg:person.01201457755.05 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
167 schema:familyName Pitulis
168 schema:givenName N.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201457755.05
170 rdf:type schema:Person
171 sg:person.01210450421.25 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
172 schema:familyName Milathianakis
173 schema:givenName C.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210450421.25
175 rdf:type schema:Person
176 sg:person.0750525645.03 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
177 schema:familyName Sourla
178 schema:givenName A.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750525645.03
180 rdf:type schema:Person
181 sg:person.0750632422.73 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
182 schema:familyName Sotiriou
183 schema:givenName E.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750632422.73
185 rdf:type schema:Person
186 sg:pub.10.1007/978-1-4419-9129-4_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035857135
187 https://doi.org/10.1007/978-1-4419-9129-4_11
188 rdf:type schema:CreativeWork
189 sg:pub.10.1007/978-1-4419-9129-4_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022910385
190 https://doi.org/10.1007/978-1-4419-9129-4_9
191 rdf:type schema:CreativeWork
192 sg:pub.10.1007/bf00665959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007810013
193 https://doi.org/10.1007/bf00665959
194 rdf:type schema:CreativeWork
195 sg:pub.10.1007/bf03401935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074687025
196 https://doi.org/10.1007/bf03401935
197 rdf:type schema:CreativeWork
198 sg:pub.10.1007/bf03402030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075215478
199 https://doi.org/10.1007/bf03402030
200 rdf:type schema:CreativeWork
201 sg:pub.10.1023/a:1025860214891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022506022
202 https://doi.org/10.1023/a:1025860214891
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/nrc867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016286671
205 https://doi.org/10.1038/nrc867
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/sj.cgt.7700665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049796132
208 https://doi.org/10.1038/sj.cgt.7700665
209 rdf:type schema:CreativeWork
210 sg:pub.10.1054/bjoc.2001.1804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003601096
211 https://doi.org/10.1054/bjoc.2001.1804
212 rdf:type schema:CreativeWork
213 sg:pub.10.2165/00002512-200320090-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026094172
214 https://doi.org/10.2165/00002512-200320090-00005
215 rdf:type schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1064243169 schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1074508230 schema:CreativeWork
218 https://app.dimensions.ai/details/publication/pub.1074714403 schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1075055239 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1075104066 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1075208230 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1075250668 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1075314244 schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1077297637 schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1080629822 schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1082680495 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1082841361 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1083100669 schema:CreativeWork
229 https://doi.org/10.1002/(sici)1097-0045(19980615)36:1<14::aid-pros3>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1045707108
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1002/(sici)1097-0045(19990301)38:4<313::aid-pros7>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041487749
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1002/(sici)1097-0045(19990515)39:3<187::aid-pros7>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034964028
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1002/(sici)1097-0045(19990601)39:4<246::aid-pros5>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1012163909
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1002/(sici)1097-0142(19971015)80:8+<1546::aid-cncr4>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1042904616
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/(sici)1097-0142(19971015)80:8+<1581::aid-cncr8>3.0.co;2-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1039638941
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/(sici)1097-4644(19960401)61:1<18::aid-jcb3>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013942496
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/1097-0142(19860815)58:4<949::aid-cncr2820580424>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003826397
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/1097-0142(19880101)61:1<195::aid-cncr2820610133>3.0.co;2-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1028158765
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/1097-0142(19890601)63:11<2234::aid-cncr2820631130>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1045013388
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/cncr.10788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043974477
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/cncr.11136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003123611
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/pros.10231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041917571
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1002/pros.10233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004039800
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1002/pros.10349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005424138
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1002/pros.10363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042270951
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1002/pros.10370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004084844
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1002/pros.20030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045794958
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/pros.2990090202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013103058
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/pros.2990270508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020573125
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1006/bbrc.1993.1506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008709902
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/0090-4295(79)90280-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051532165
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.urology.2003.08.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046698092
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0033-8389(05)70153-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028078731
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0090-4295(01)01405-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013051979
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0090-4295(02)01589-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053503373
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0090-4295(98)00182-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003279232
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0305-7372(03)00071-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048240448
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1046/j.1532-5415.2003.51367.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022331769
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1073/pnas.93.14.7263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025701476
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1074/jbc.m304494200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037862682
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1074/jbc.m308158200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034818392
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1093/jnci/94.1.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049172180
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1093/jnci/94.1.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036789218
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1093/jnci/95.6.458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038366969
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1097/01.blo.0000093047.96273.4e schema:sameAs https://app.dimensions.ai/details/publication/pub.1038708593
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1172/jci113186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050756254
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1172/jci11685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046571956
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1200/jco.20.3.833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202804
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1210/jcem.86.12.8119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064324084
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1309/vxkk-yvrh-9b11-ydpt schema:sameAs https://app.dimensions.ai/details/publication/pub.1048953330
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1359/jbmr.2003.18.2.190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020641054
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1517/13543784.10.6.1099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012312469
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1517/13543784.11.2.283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021919522
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1677/erc.0.0100279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050383095
318 rdf:type schema:CreativeWork
319 https://doi.org/10.2174/1389450033346830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069180091
320 rdf:type schema:CreativeWork
321 https://doi.org/10.3892/or.5.6.1389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071535802
322 rdf:type schema:CreativeWork
323 https://www.grid.ac/institutes/grid.5216.0 schema:alternateName National and Kapodistrian University of Athens
324 schema:name Department of Experimental Physiology, Medical School, University of Athens, Goudi-Athens, 115 27, Greece
325 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...