Agonists of Toll-Like Receptor 9 View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2005-01-01

AUTHORS

Ekambar R. Kandimalla , Sudhir Agrawal

ABSTRACT

Innate immunity is the body’s first line of defense against invading microbes. This component of our immune system relies on highly conserved pattern-recognition receptors (PRRs) to distinguish different pathogens. Toll-like receptors (TLRs) are one class of PRR of which ten (TLRl-10) have now been identified in mammals. TLRs recognize pathogen-associated molecular patterns (PAMPs) and initiate the appropriate immune responses. These entail the activation of signal cascades leading to the secretion of cytokines, the activation of cell-surface molecules and the production of pathogen-specific immunoglobulins (Ig). As TLRs are constitutively expressed on immune cells and are responsive to synthetic ligands, they provide us with a rational way with which to modulate the immune system; a strategy which can be seen as quite distinct from conventional vaccination. More... »

PAGES

181-212

Book

TITLE

Toll and Toll-Like Receptors: An Immunologic Perspective

ISBN

978-0-306-48237-3
978-0-387-27445-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/0-387-27445-6_10

DOI

http://dx.doi.org/10.1007/0-387-27445-6_10

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036583074


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