BDNF Preferentially Targets Membrane Properties of Rhythmically Active Neurons in the pre-Bötzinger Complex in Neonatal Mice View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2004

AUTHORS

Muriel Thoby-Brisson , Sandra Autran , Gilles Fortin , Jean Champagnat

ABSTRACT

Neurotrophins are a class of factors known to be involved in the development, maintenance, plasticity and survival of the peripheral and central nervous systems1. Neurotrophins are active through high-affinity receptors having an intrinsic tyrosine-kinase activity2,3. One of these neurotrophins, the brain-derived neurotrophic factor (BDNF) has been shown to be involved in a wide range of developmental and plasticity mechanisms and its biological action depends mainly upon activation of the TrkB receptor sub-type and to a less extent to the p75 receptors. BDNF binding on TrkB receptors initiates a cascade of events of phosphorylation that activate a complex of signal proteins and the induction of several genes4. More... »

PAGES

115-120

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/0-387-27023-x_18

DOI

http://dx.doi.org/10.1007/0-387-27023-x_18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002283117

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15602952


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