Ontology type: schema:Chapter
2005
AUTHORSJohn T. Slevin , Sidney W. Whiteheart , Thomas C. Vanaman
ABSTRACTApplication of the newly developed tools of proteomics analysis to the brain is still at an early stage of development. Primary application of 2D gel electrophoresis coupled with mass spectrometry based protein identification has been primarily directed at analyzing whole brain proteomes. As has been recently reviewed,1 this has led to the identification of a number of the more abundant brain proteins but has yet to focus on the important functional sub-compartments of the neuron (e.g., the synapse) or to probe for potential changes in disease states. This, in part, reflects a major limitation of protein profiling: the inherent complexity of proteomes even of subcellular compartments. We have begun to establish 2D gel maps for rat hippocampal synaptosomes and sub-fractions (synaptosol, plasma membrane and vesicle fractions) in both the resting and depolarized state. In this chapter we demonstrate how this technique can be applied to the study of kindled epilepsy. More... »
PAGES189-197
Kindling 6
ISBN978-0-387-24380-1
http://scigraph.springernature.com/pub.10.1007/0-387-26144-3_19
DOIhttp://dx.doi.org/10.1007/0-387-26144-3_19
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1023929487
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Lexington VA Medical Center",
"id": "https://www.grid.ac/institutes/grid.413837.a",
"name": [
"VA Medical Center, 40502, Lexington, KY"
],
"type": "Organization"
},
"familyName": "Slevin",
"givenName": "John T.",
"id": "sg:person.014711244307.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014711244307.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Albert B. Chandler Hospital",
"id": "https://www.grid.ac/institutes/grid.461341.5",
"name": [
"University of Kentucky Medical Center, 40536, Lexington, KY"
],
"type": "Organization"
},
"familyName": "Whiteheart",
"givenName": "Sidney W.",
"id": "sg:person.01121304105.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121304105.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Albert B. Chandler Hospital",
"id": "https://www.grid.ac/institutes/grid.461341.5",
"name": [
"University of Kentucky Medical Center, 40536, Lexington, KY"
],
"type": "Organization"
},
"familyName": "Vanaman",
"givenName": "Thomas C.",
"id": "sg:person.01225453513.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225453513.24"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1074/jbc.c300189200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000175981"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0076-6879(91)01043-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010349990"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/227680a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010419937",
"https://doi.org/10.1038/227680a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/pmic.200300545",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016838430"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-8993(90)90395-r",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019488416"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-8993(90)90395-r",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019488416"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-8993(88)91383-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024072968"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-8993(88)91383-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024072968"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1471-4159.1985.tb07118.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028951272"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0301-0082(03)00036-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035709017"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0301-0082(03)00036-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035709017"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0013-4694(72)90177-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047420585"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0013-4694(72)90177-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047420585"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1522-2683(200106)22:10<2086::aid-elps2086>3.0.co;2-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048239848"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079446853",
"type": "CreativeWork"
}
],
"datePublished": "2005",
"datePublishedReg": "2005-01-01",
"description": "Application of the newly developed tools of proteomics analysis to the brain is still at an early stage of development. Primary application of 2D gel electrophoresis coupled with mass spectrometry based protein identification has been primarily directed at analyzing whole brain proteomes. As has been recently reviewed,1 this has led to the identification of a number of the more abundant brain proteins but has yet to focus on the important functional sub-compartments of the neuron (e.g., the synapse) or to probe for potential changes in disease states. This, in part, reflects a major limitation of protein profiling: the inherent complexity of proteomes even of subcellular compartments. We have begun to establish 2D gel maps for rat hippocampal synaptosomes and sub-fractions (synaptosol, plasma membrane and vesicle fractions) in both the resting and depolarized state. In this chapter we demonstrate how this technique can be applied to the study of kindled epilepsy.",
"editor": [
{
"familyName": "Corcoran",
"givenName": "Michael E.",
"type": "Person"
},
{
"familyName": "Mosh\u00e9",
"givenName": "Solomon L.",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/0-387-26144-3_19",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": {
"isbn": [
"978-0-387-24380-1"
],
"name": "Kindling 6",
"type": "Book"
},
"name": "A Proteomic Approach to the Molecular Analysis of Kindling",
"pagination": "189-197",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/0-387-26144-3_19"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"7200ccdca81dabb2b2fc1a04ee3e60f7a0119ffe0f51dbeb1994cc753cac47d0"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1023929487"
]
}
],
"publisher": {
"location": "Boston, MA",
"name": "Springer US",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/0-387-26144-3_19",
"https://app.dimensions.ai/details/publication/pub.1023929487"
],
"sdDataset": "chapters",
"sdDatePublished": "2019-04-16T05:50",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89826_00000001.jsonl",
"type": "Chapter",
"url": "https://link.springer.com/10.1007%2F0-387-26144-3_19"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/0-387-26144-3_19'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/0-387-26144-3_19'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/0-387-26144-3_19'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/0-387-26144-3_19'
This table displays all metadata directly associated to this object as RDF triples.
119 TRIPLES
23 PREDICATES
38 URIs
20 LITERALS
8 BLANK NODES