LHRH antagonists: new preclinical and clinical results View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2002

AUTHORS

B. Kutscher , M. Bernd , W. Deger , T. Reissmann , R. Deghenghi , J. Engel

ABSTRACT

TeverelixINN (Antarelix) and D-26344, a D-Lys-6-analogue of Cetrorelix, show excellent human LHRH-receptor affinity, long lasting testosterone suppression in rats up to 648 hours (D-26344), and minimal histamine release. Both compounds are currently in preclinical evaluation at ASTA Medica for treatment of sex-hormone dependent tumors. Several non-malignant conditions such as benign prostatic hyperplasia are also possibly appreciate targets for these LHRH antagnist. More... »

PAGES

264-268

Book

TITLE

Peptides Biology and Chemistry

ISBN

0-7923-6279-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/0-306-46880-8_67

DOI

http://dx.doi.org/10.1007/0-306-46880-8_67

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001215342


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