Establishing and Developing Cho Cell Lines for the Commercial Productoin of Human Anti-Rhesus D IgG View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1999

AUTHORS

M. J. De Jesus , M. Bourgeois , M. Jordan , M. Zahn , N. Mermod , H. Amstutz , F. M. Wurm

ABSTRACT

Hemolytic Disease of the Newborn (HDN) can be a life threatening condition in Rhesus D positive babies born from Rhesus D negative mothers. Successful prophylaxis in mothers is commonly based on the use of plasma-derived anti-D immunoglobulin preparations, which are rapidly becoming a scarce resource. In consequence, the substitution of the human derived polyclonal anti-D is both a health and an ethical concern. Several groups are involved in the expression of immunoglobulins anti Rh D in different hosts, including fused EBV-transformed human lymphocytes with murine myeloma (only IgG1) (Olovnikova, Belkina et al. 1997) and EBV-transformed B-lymphoblastoid cell lines (IgG1 and IgG3 subclasses) (Kumpel 1997). Among all the eukaryotic expression systems, CHO cells are still the most popular cell host for the production of recombinant proteins as human therapeutic agents (Wurm 1997), because of safety considerations, as well as practical issues related to scale up. More... »

PAGES

91-93

Book

TITLE

Animal Cell Technology: Products from Cells, Cells as Products

ISBN

978-0-7923-6075-9
978-0-306-46875-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/0-306-46875-1_20

DOI

http://dx.doi.org/10.1007/0-306-46875-1_20

DIMENSIONS

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