Fibroblast Growth Factor Signalling and Cyclin D1 Function are Necessary for Normal Mammary Gland Development during Pregnancy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2002

AUTHORS

Vera Fantl , Anna Creer , Christian Dillon , Janine Bresnick , David Jackson , Paul Edwards , Ian Rosewell , Clive Dickson

ABSTRACT

A number of growth factors, growth factor receptors and cell cycle regulatory proteins have been implicated in the genesis of mammary carcinomas both in animal models as well as in human breast tumour samples. Studies on the development of the mammary gland has revealed that several of the proto-oncogenes, or their closely related gene-family members, have a function in the normal growth and differentiation of the gland. In this review the role of fibroblast growth factor signalling and the critical requirement for the cell cycle regulator, cyclin D1 is discussed with respect to their normal function in mammary gland development and abnormal role in mammary carcinogenesis. More... »

PAGES

1-7

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/0-306-46832-8_1

DOI

http://dx.doi.org/10.1007/0-306-46832-8_1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031531958

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10959404


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