The Influence of Adrenal Steroids on Macrophage and T-cell Function in Tuberculosis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2002-01-01

AUTHORS

Graham A. W. Rook , Rogelio Hernandez-Pando

ABSTRACT

ConclusionsIn tuberculosis patients there ar several changes in the production, diurnal rhythm, and peripheral m tabolism of GCs and of DHEA that will r sult in an increase in the total impact of GCs on T cells and macrophages in each 24-h period. The long-term effect of increased GC-mediated gene regulation is to terminate Th1 activity and deviate the immune system toward a Th2 cytokine profile. In tuberculosis even a minor Th2 component is sufficient to undermine the efficacy of immunity.Preimmunization to establish a Th2 component before infection results in animals that are more susceptible to the disease than are nonimmunized controls.48 In progressive human tuberculosis the Th1 response remains dominant,but there is conclusive evidence for the simultaneous presence of an inappropriate Th2 component. This may represent an attempt by the HPA axis to cause premature termination of the Th1 response. Recent attempts to manipulate murine tuberculosis by purely endocrine means lend support to this concept, and suggest that endocrine-based therapies may become a reality. More... »

PAGES

55-73

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/0-306-46809-3_4

DOI

http://dx.doi.org/10.1007/0-306-46809-3_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026435819


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