Alfred Singer

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Publications in SciGraph latest 50 shown

  • 2018-12 CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation in NATURE COMMUNICATIONS
  • 2018-12 A TCR mechanotransduction signaling loop induces negative selection in the thymus in NATURE IMMUNOLOGY
  • 2017-11 Identification of lineage-specifying cytokines that signal all CD8+-cytotoxic-lineage-fate 'decisions' in the thymus in NATURE IMMUNOLOGY
  • 2016-12 Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors in NATURE IMMUNOLOGY
  • 2015-10 TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells in NATURE IMMUNOLOGY
  • 2015-05 Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function in NATURE IMMUNOLOGY
  • 2014-07 The transcription factor ThPOK suppresses Runx3 and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling in NATURE IMMUNOLOGY
  • 2013-02 IL-7 signaling must be intermittent, not continuous, during CD8+ T cell homeostasis to promote cell survival instead of cell death in NATURE IMMUNOLOGY
  • 2012-06 Clonal deletion and the fate of autoreactive thymocytes that survive negative selection in NATURE IMMUNOLOGY
  • 2010-03 Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells in NATURE IMMUNOLOGY
  • 2008-10 Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice in NATURE REVIEWS IMMUNOLOGY
  • 2007-10 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR in NATURE IMMUNOLOGY
  • 2005-02 CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2 in NATURE IMMUNOLOGY
  • 2002-06 Early TCRα expression generates TCRαγ complexes that signal the DN-to-DP transition and impair development in NATURE IMMUNOLOGY
  • 1990-03 Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4 in NATURE
  • 1989-10 Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain in NATURE
  • 1989 Developmental Arrest of T Cell Receptor (TcR) Negative SCID Thymocytes and Release in the Presence of TcR+ Cells in PROGRESS IN IMMUNOLOGY
  • 1988-11 Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes in NATURE
  • 1986-03 AIDS therapy by blocking CD4+ cells in NATURE
  • 1985-10 T-cell recognition of a chimaeric class II/class I MHC molecule and the role of L3T4 in NATURE
  • 1983-09 Major histocompatibility complex-restricted recognition by B lymphocytes and accessory cells in IMMUNOLOGIC RESEARCH
  • 1983 Ir Gene Regulation of The T Cell Dependent Activation of Distinct B Cell Subpopulations in IR GENES
  • 1980 Expression of Ir Genes and Ia Antigens by Adherent Accessory Cells Required for Antigen-Specific Antibody-Forming Cell Responses in MONONUCLEAR PHAGOCYTES
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