Mark J Mckeage

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Mark J



Publications in SciGraph latest 50 shown

  • 2018-02 Phase IB Trial of the Anti-Cancer Stem Cell DLL4-Binding Agent Demcizumab with Pemetrexed and Carboplatin as First-Line Treatment of Metastatic Non-Squamous NSCLC in TARGETED ONCOLOGY
  • 2017-12 Predicting effects on oxaliplatin clearance: in vitro, kinetic and clinical studies of calcium- and magnesium-mediated oxaliplatin degradation in SCIENTIFIC REPORTS
  • 2017-10 EGFR Mutation Testing of non-squamous NSCLC: Impact and Uptake during Implementation of Testing Guidelines in a Population-Based Registry Cohort from Northern New Zealand in TARGETED ONCOLOGY
  • 2014-07 Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2013-12 Phase I drug-interaction study of effects of calcium and magnesium infusions on oxaliplatin pharmacokinetics and acute neurotoxicity in colorectal cancer patients in BMC CANCER
  • 2012-12 PR-104 a bioreductive pre-prodrug combined with gemcitabine or docetaxel in a phase Ib study of patients with advanced solid tumours in BMC CANCER
  • 2012-05 Mass balance, excretion and metabolism of [14C] ASA404 in cancer patients in a phase I trial in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2011-12 A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients in BMC CANCER
  • 2010-12 Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue in MOLECULAR PAIN
  • 2010-12 Detecting acute neurotoxicity during platinum chemotherapy by neurophysiological assessment of motor nerve hyperexcitability in BMC CANCER
  • 2009-12 Oxaliplatin-induced loss of phosphorylated heavy neurofilament subunit neuronal immunoreactivity in rat DRG tissue in MOLECULAR PAIN
  • 2009-09 Neuronal expression of copper transporter 1 in rat dorsal root ganglia: association with platinum neurotoxicity in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2008-12 Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer in BRITISH JOURNAL OF CANCER
  • 2008-11 Professor Lloyd R. Kelland: man of science in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2007-04 Satraplatin in Hormone-Refractory Prostate Cancer and Other Tumour Types in DRUGS
  • 2007-04 Antitumour action of 5,6-dimethylxanthenone-4-acetic acid in rats bearing chemically induced primary mammary tumours in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2006-05 5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA) in AMERICAN JOURNAL OF CANCER
  • 2006-04 Satraplatin activation by haemoglobin, cytochrome C and liver microsomes in vitro in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2005-10 Oxaliplatin causes selective atrophy of a subpopulation of dorsal root ganglion neurons without inducing cell loss in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2003-09 Pemetrexed in AMERICAN JOURNAL OF CANCER
  • 2003-06 Paclitaxel induces nucleolar enlargement in dorsal root ganglion neurons in vivo reducing oxaliplatin toxicity in BRITISH JOURNAL OF CANCER
  • 2003-01 Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2002-07 Rapid biotransformation of satraplatin by human red blood cells in vitro in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2001-10 Nucleolar damage correlates with neurotoxicity induced by different platinum drugs in BRITISH JOURNAL OF CANCER
  • 2000-11 Increased targeting of adenine-rich sequences by (2-amino-2-methyl-3-butanone oxime)dichloroplatinum(II) and investigations into its low cytotoxicity in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2000-11 Role of lipophilicity in determining cellular uptake and antitumour activity of gold phosphine complexes in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2000-02 Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs in BRITISH JOURNAL OF CANCER
  • 1997-08 Stereoselective peripheral sensory neurotoxicity of diaminocyclohexane platinum enantiomers related to ormaplatin and oxaliplatin in BRITISH JOURNAL OF CANCER
  • 1996 The Clinical Development of the Oral Platinum Anticancer Agent JM216 in PLATINUM AND OTHER METAL COORDINATION COMPOUNDS IN CANCER CHEMOTHERAPY 2
  • 1995-11 A phase I and pharmacology study of an oral platinum complex, JM216: dose-dependent pharmacokinetics with single-dose administration in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1995-10 Comparative Adverse Effect Profiles of Platinum Drugs in DRUG SAFETY
  • 1994-11 Preclinical toxicology and tissue platinum distribution of novel oral antitumour platinum complexes: ammine/amine platinum(IV) dicarboxylates in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1994-08 New Platinum Agents in DRUGS & AGING
  • 1994-01 Mechanism of action of an orally administered platinum complex [ammine bis butyrato cyclohexylamine dichloroplatinum (IV) (JM221)] in intrinsically cisplatin-resistant human ovarian carcinoma in vitro in BRITISH JOURNAL OF CANCER
  • 1993-05 Lack of nephrotoxicity of oral ammine/amine platinum (IV) dicarboxylate complexes in rodents in BRITISH JOURNAL OF CANCER
  • 1992-05 A clinical and pharamcological study of high-dose mitozolomide given in conjunction with autologous bone marrow rescue in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1991-11 Plasma pharmacokinetics of the antitumour agents 5,6-dimethylxanthenone-4-acetic acid, xanthenone-4-acetic acid and flavone-8-acetic acid in mice in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1991-11 Haematological effects in mice of the antitumour agents xanthenone-4-acetic acid, 5,6-methyl-xanthenone-4-acetic acid and flavone acetic acid in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1991-10 Platinum and other metal coordination compounds in cancer chemotherapy. A commentary on the sixth international symposium: San Diego, California, 23-26th January 1991 in BRITISH JOURNAL OF CANCER
  • 1989-08 Mitozolomide-induced sensitisation of mammalian cells in vitro to radiation in BRITISH JOURNAL OF CANCER
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