William Vainchenker

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Publications in SciGraph latest 50 shown

  • 2019-03 Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice in ONCOGENE
  • 2017-12 Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect in NATURE COMMUNICATIONS
  • 2017-08 Non-apoptotic functions of caspases in myeloid cell differentiation in CELL DEATH & DIFFERENTIATION
  • 2016-12 CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress in SCIENTIFIC REPORTS
  • 2016-08 Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin in LEUKEMIA
  • 2016-08 Thrombopoietin receptor is required for the oncogenic function of CALR mutants in LEUKEMIA
  • 2016-02-24 Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents in NATURE COMMUNICATIONS
  • 2015-03 Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation in ONCOGENE
  • 2015-01 Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution in LEUKEMIA
  • 2014-03 The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases in LEUKEMIA
  • 2014-02 Use of the 46/1 haplotype to model JAK2V617F clonal architecture in PV patients: clonal evolution and impact of IFNα treatment in LEUKEMIA
  • 2014-02 JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma in LEUKEMIA
  • 2013-11 A role for reactive oxygen species in JAK2V617F myeloproliferative neoplasm progression in LEUKEMIA
  • 2013-07 Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms in CELL DEATH & DISEASE
  • 2013-06 Myelofibrosis, JAK2 inhibitors and erythropoiesis in LEUKEMIA
  • 2013-05 JAK/STAT signaling in hematological malignancies in ONCOGENE
  • 2012-10 CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model in CELL DEATH & DISEASE
  • 2012-07 Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro in CELL DEATH & DISEASE
  • 2012-05 Does increasing the JAK2V617F assay sensitivity allow to identify more patients with MPN? in BLOOD CANCER JOURNAL
  • 2012-03 JAK2V617F negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative neoplasms in ONCOGENE
  • 2012-01 RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization in NATURE COMMUNICATIONS
  • 2011-04 Caspase-activated ROCK-1 allows erythroblast terminal maturation independently of cytokine-induced Rho signaling in CELL DEATH & DIFFERENTIATION
  • 2010-08 Clonal analysis of erythroid progenitors suggests that pegylated interferon α-2a treatment targets JAK2V617F clones without affecting TET2 mutant cells in LEUKEMIA
  • 2010-06 The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development in LEUKEMIA
  • 2009-11 Mutations of ASXL1 gene in myeloproliferative neoplasms in LEUKEMIA
  • 2009-06 SOCS3 inhibits TPO-stimulated, but not spontaneous, megakaryocytic growth in primary myelofibrosis in LEUKEMIA
  • 2009-05 TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis in LEUKEMIA
  • 2009-03 Alterations of NFIA in chronic malignant myeloid diseases in LEUKEMIA
  • 2009-01 Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineage in LEUKEMIA
  • 2008-11 BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders: some common and contrasting features in LEUKEMIA
  • 2008-11 Miscreant myeloproliferative disorder stem cells in LEUKEMIA
  • 2008-08 New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition in LEUKEMIA
  • 2008-03 In vitro and in vivo evaluation of the haematopoietic potential of skeletal muscle in a non-human primate model in BONE MARROW TRANSPLANTATION
  • 2007-12 Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice in RESPIRATORY RESEARCH
  • 2007-09 Quantitative and qualitative in vitro analysis of the stem cell potential of hematopoietic cells purified from murine skeletal muscle in CELL RESEARCH
  • 2007-05 p210<b><sup>BCR-ABL</sup></b> reprograms transformed and normal human megakaryocytic progenitor cells into erythroid cells and suppresses FLI-1 transcription in LEUKEMIA
  • 2006-12 Oncogenic mechanisms in myeloproliferative disorders in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2006-10 Oncogenic kinases of myeloproliferative disorders induce both protein synthesis and G1 activators in LEUKEMIA
  • 2006-02 Detection of JAK2 V617F as a first intention diagnostic test for erythrocytosis in LEUKEMIA
  • 2005-04 A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera in NATURE
  • 2005-04 A lentiviral vector encoding the human Wiskott–Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice in GENE THERAPY
  • 2004-06-21 Isolation and Culture of Megakaryocyte Precursors in PLATELETS AND MEGAKARYOCYTES
  • 2004-05 Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy in ONCOGENE
  • 2004-04 Membrane-bound Delta-4 Notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential in LEUKEMIA
  • 2003-06 Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells in ONCOGENE
  • 2003-04 Antiviral agent Cidofovir decreases Epstein–Barr virus (EBV) oncoproteins and enhances the radiosensitivity in EBV-related malignancies in ONCOGENE
  • 2002-11 Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant in ONCOGENE
  • 2002-04 Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers in ONCOGENE
  • 2001-10 Rapid generation of a tetracycline-inducible BCR-ABL defective retrovirus using a single autoregulatory retroviral cassette in LEUKEMIA
  • 2001-09 Germ-line deletion of p53 reveals a multistage tumor progression in spi-1/PU.1 transgenic proerythroblasts in ONCOGENE
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