Edward M Sellers

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Edward M



Publications in SciGraph latest 50 shown

  • 2014-12 The US FDA Draft Guidance for Developing Abuse-Deterrent Opioid Analgesics: 2014 and Beyond in PHARMACEUTICAL MEDICINE
  • 2014-09 Brain Network Activation (BNA) Reveals Scopolamine-Induced Impairment of Visual Working Memory in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2014-04 Assessment of the Abuse Liability of a Dual Orexin Receptor Antagonist: A Crossover Study of Almorexant and Zolpidem in Recreational Drug Users in CNS DRUGS
  • 2012-08 A Study of Potential Pharmacokinetic and Pharmacodynamic Interactions between Dextromethorphan/Quinidine and Memantine in Healthy Volunteers in CLINICAL DRUG INVESTIGATION
  • 2012-08 A study of potential pharmacokinetic and pharmacodynamic interactions between dextromethorphan/quinidine and memantine in healthy volunteers. in CLINICAL DRUG INVESTIGATION
  • 2012-03 Randomized Open-Label Drug-Drug Interaction Trial of Dextromethorphan/Quinidine and Paroxetine in Healthy Volunteers in CLINICAL DRUG INVESTIGATION
  • 2010-07 Subjective and Objective Effects of the Novel Triple Reuptake Inhibitor Tesofensine in Recreational Stimulant Users in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2009-12 Subjective Effects and Safety of Whole and Tampered Morphine Sulfate and Naltrexone Hydrochloride (ALO-01) Extended-Release Capsules versus Morphine Solution and Placebo in Experienced Non-Dependent Opioid Users in CLINICAL DRUG INVESTIGATION
  • 2009-08 A novel CYP2A6 allele (CYP2A635CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo in THE PHARMACOGENOMICS JOURNAL
  • 2006-06 Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study in PSYCHOPHARMACOLOGY
  • 2006-06 Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2005-03 Nicotine physical dependence and tolerance in the mouse following chronic oral administration in PSYCHOPHARMACOLOGY
  • 2005-03 Implications of CYP2A6 Genetic Variation for Smoking Behaviors and Nicotine Dependence in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2004-09 EMD 281014, a specific and potent 5HT2 antagonist in humans: a dose-finding PET study in PSYCHOPHARMACOLOGY
  • 2004-02 Oral ketamine as a positive control in abuse liability studies in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2003-12 Alcohol withdrawal severity is decreased by symptom-orientated adjusted bolus therapy in the ICU in INTENSIVE CARE MEDICINE
  • 2003-11 Combined phenotypic assessment of cytochrome P450 1A2, 2C9, 2C19, 2D6, and 3A, N‐acetyltransferase‐2, and xanthine oxidase activities with the “Cooperstown 5+1 cocktail” in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2003-02 Effect of oral contraceptives (OCS) on drug metabolizing enzymes (DMES) as measured by the validated cooperstown 5+1 cocktail (5+1) in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2003-02 Measurement issues in postpartum depression part 1: Anxiety as a feature of postpartum depression in ARCHIVES OF WOMEN'S MENTAL HEALTH
  • 2003-02 Measurement issues in postpartum depression part 2: Assessment of somatic symptoms using the Hamilton Rating Scale for Depression in ARCHIVES OF WOMEN'S MENTAL HEALTH
  • 2003-02 Lack of correlation between CYP3A probes and midazolam in healthy caucasian women on or off oral contraceptives (OCS) in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2002-08 Effect of sex and menstrual cycle phase on cytochrome P450 2C19 activity with omeprazole used as a biomarker in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2000-07 Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2000-05 Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations in MOLECULAR PSYCHIATRY
  • 2000 The Interaction of the Serotoninergic and Other Neuroregulatory Systems in Alcohol Dependence in SEROTONINERGIC NEURONS AND 5-HT RECEPTORS IN THE CNS
  • 1999-02 Ecopipam (SCH 39166), A D1 antagonist, on acute effects of cocaine in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1999-02 Patterns of benzodiazepine (B) use and dependence in Canada in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1999-02 Inhibition of CYP2A6 decreases smoking in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1998-10 Canadian Native Indians exhibit unique CYP2A6 and CYP2C19 mutant allele frequencies in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1998-06 Nicotine metabolism defect reduces smoking in NATURE
  • 1997-12 An improved HPLC method for analysis of methamphetamine and its metabolites in plasma in EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
  • 1997-12 Comparison of CYP2A6 catalytic activity on coumarin 7-hydroxylation in human and monkey liver microsomes in EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
  • 1997-09 Paroxetine potentiates the central nervous system side effects of perphenazine: Contribution of cytochrome P4502D6 inhibition in vivo in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1996-02 Severe Dependence on Oral Opiates in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1996-02 Psychiatric Comorbidity and Dependence in Regular Users of Codeine in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1996-02 Does Extent of p‐Hydroxylation Alter Methamphetamine Kinetics in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1994-06 Low doses of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake in PSYCHOPHARMACOLOGY
  • 1994-05 Influence of 5-HT3 receptor antagonists and the indirect 5-HT agonist, dexfenfluramine, on heroin self-administration in rats in PSYCHOPHARMACOLOGY
  • 1994-04 Pharmacologic effects and abuse liability of bretazenil, diazepam, and alprazolam in humans in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1993-11 CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1993-08 Effect of 5-HT3 receptor antagonists on the discriminative stimulus properties of morphine in rats in PSYCHOPHARMACOLOGY
  • 1993-04 Inhibition by fluoxetine of cytochrome P450 2D6 activity in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1992-03 Effect of the 5-HT3 receptor antagonists, MDL72222 and ondansetron on morphine place conditioning in PSYCHOPHARMACOLOGY
  • 1992 Medications for Alcohol Abuse and Dependence: Methodology for Clinical Studies in NOVEL PHARMACOLOGICAL INTERVENTIONS FOR ALCOHOLISM
  • 1992 Perception of Whether Drug or Placebo has been Administered is a Determinant of Drinking Reduction in NOVEL PHARMACOLOGICAL INTERVENTIONS FOR ALCOHOLISM
  • 1991-11 Effects of 5-HT3 receptor antagonists on behavioural measures of naloxone-precipitated opioid withdrawal in PSYCHOPHARMACOLOGY
  • 1991-07 Enalapril effects on alcohol intake and other consummatory behaviors in alcoholics in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1990-04 Fluoxetine differentially alters alcohol intake and other consummatory behaviors in problem drinkers in CLINICAL PHARMACOLOGY & THERAPEUTICS
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