David B Solit

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Person Info


David B



Publications in SciGraph latest 50 shown

  • 2019-03 Phase II study of trastuzumab with modified docetaxel, cisplatin, and 5 fluorouracil in metastatic HER2-positive gastric cancer in GASTRIC CANCER
  • 2019-02 Tumor mutational load predicts survival after immunotherapy across multiple cancer types in NATURE GENETICS
  • 2018-09 Clinical tumour sequencing for precision oncology: time for a universal strategy in NATURE REVIEWS CANCER
  • 2018-08 Genome doubling shapes the evolution and prognosis of advanced cancers in NATURE GENETICS
  • 2018-07 Rates of TP53 Mutation are Significantly Elevated in African American Patients with Gastric Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2018-02 HER kinase inhibition in patients with HER2- and HER3-mutant cancers in NATURE
  • 2017-12 3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets in GENOME MEDICINE
  • 2017-12 A phase I trial of ganetespib in combination with paclitaxel and trastuzumab in patients with human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer in BREAST CANCER RESEARCH
  • 2017-08 Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS in NATURE
  • 2017-06 Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients in NATURE MEDICINE
  • 2016-04 Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer in NATURE GENETICS
  • 2016-02 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity in NATURE BIOTECHNOLOGY
  • 2015-02 Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor in NATURE
  • 2014-08 Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions in GENOME BIOLOGY
  • 2013-11 Tumor adaptation and resistance to RAF inhibitors in NATURE MEDICINE
  • 2013-03 Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation in NATURE GENETICS
  • 2012-10 Targeted next-generation sequencing of colorectal cancer identified metastatic specific genetic alterations in BMC PROCEEDINGS
  • 2012-08 Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
  • 2012-07 Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion in NATURE
  • 2012-07 Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2012-06 Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer in NATURE
  • 2012-04 A phase I trial of docetaxel and pulse-dose 17-allylamino-17-demethoxygeldanamycin in adult patients with solid tumors in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2012-03 Translational medicine: Primed for resistance in NATURE
  • 2012-01 Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring V600EBRAF in ONCOGENE
  • 2011-12 RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) in NATURE
  • 2011-12 The “SWOT” of BRAF Inhibition in Melanoma: RAF Inhibitors, MEK Inhibitors or Both? in CURRENT ONCOLOGY REPORTS
  • 2011-10 Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion in NATURE GENETICS
  • 2011-08-05 Targeting Oncogenic BRAF in Human Cancer in THERAPEUTIC KINASE INHIBITORS
  • 2010-12 Drug discovery: How melanomas bypass new therapy in NATURE
  • 2010-10 Tracing cancer networks with phosphoproteomics in NATURE BIOTECHNOLOGY
  • 2010-01 Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth in ONCOGENE
  • 2010-01 Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies in NATURE GENETICS
  • 2008-01 Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo in NATURE BIOTECHNOLOGY
  • 2007-12 A polyvalent vaccine for high-risk prostate patients: “are more antigens better?” in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2007-03 A phase I trial of intermittent high-dose gefitinib and fixed-dose docetaxel in patients with advanced solid tumors in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2006-01 BRAF mutation predicts sensitivity to MEK inhibition in NATURE
  • 2004-06 Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors in NATURE BIOTECHNOLOGY
  • 2002-02 Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2 in ONCOGENE
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