Gregory B Lesinski B Lesinski

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Gregory B Lesinski B



Publications in SciGraph latest 50 shown

  • 2022-02-23 Modulation of the tumor microenvironment by armed vesicular stomatitis virus in a syngeneic pancreatic cancer model in VIROLOGY JOURNAL
  • 2021-09-30 The tumor microenvironment in pancreatic ductal adenocarcinoma: current perspectives and future directions in CANCER AND METASTASIS REVIEWS
  • 2021-06-23 A multi-center, single-arm, phase Ib study of pembrolizumab (MK-3475) in combination with chemotherapy for patients with advanced colorectal cancer: HCRN GI14-186 in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2021-05-13 Pepinemab (Anti-SEMA4D) in Combination with Ipilimumab or Nivolumab for Patients with Resectable Pancreatic and Colorectal Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2020-08-04 Suppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease in BRITISH JOURNAL OF CANCER
  • 2019-10-14 Immune checkpoint inhibitors for the treatment of MSI-H/MMR-D colorectal cancer and a perspective on resistance mechanisms in BRITISH JOURNAL OF CANCER
  • 2019-07-17 Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells through enhancing protein stabilization accompanied with enhanced β-TrCP degradation in ONCOGENE
  • 2019-03-25 Soy isoflavones and their metabolites modulate cytokine-induced natural killer cell function in SCIENTIFIC REPORTS
  • 2018-09-06 Interleukin-6/STAT3 Signaling is Prominent and Associated with Reduced Overall Survival in p16 Negative Oropharyngeal Squamous Cell Carcinoma in HEAD AND NECK PATHOLOGY
  • 2017-05-11 Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo in SCIENTIFIC REPORTS
  • 2017-04-13 Laser Capture Microdissection of Pancreatic Acinar Cells to Identify Proteomic Alterations in a Murine Model of Caerulein-Induced Pancreatitis in CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
  • 2016-08-31 A phase I study of recombinant (r) vaccinia-CEA(6D)-TRICOM and rFowlpox-CEA(6D)-TRICOM vaccines with GM-CSF and IFN-α-2b in patients with CEA-expressing carcinomas in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2016-08-02 Endoscopic Pancreas Fluid Collection: Methods and Relevance for Clinical Care and Translational Science in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2015-11-04 Selinexor, a selective inhibitor of nuclear export (SINE), shows enhanced activity in combination with PD-1/PD-L1 blockade in syngeneic murine models of colon cancer and melanoma in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2015-11-04 Anti-IL-6 and PD-L1 antibody combination therapy reduces tumor progression in murine models of pancreatic cancer in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2015-11-04 Immunological predictors of overall survival in treatment naïve metastatic pancreatic cancer patients in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2015-03-21 Gene-mediated cytotoxic immunotherapy as adjuvant to surgery or chemoradiation for pancreatic adenocarcinoma in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2014-11-06 Cholangiocarcinoma cells secrete soluble factors that activate Jak/STAT signal transduction and promote MDSC expansion in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2014-11-06 BMS-911543 inhibits viability of tumor and stromal cells and limits disease progression in genetically engineered mice with pancreatic cancer in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2014-10-11 Patients with pancreatic adenocarcinoma exhibit elevated levels of myeloid-derived suppressor cells upon progression of disease in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2014-06-04 Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2013-11-07 Genetically engineered murine pancreatic cancer models approximate immunophenotypic properties of human patients in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2012-07-13 Curcumin Analogs as Inhibitors of the Jak-STAT Signal Transduction Pathway in NOVEL APOPTOTIC REGULATORS IN CARCINOGENESIS
  • 2011-08-23 miR-21 and miR-155 are associated with mitotic activity and lesion depth of borderline melanocytic lesions in BRITISH JOURNAL OF CANCER
  • 2011-05-21 Enhanced anti-tumor activity of interferon-alpha in SOCS1-deficient mice is mediated by CD4+ and CD8+ T cells in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2011-05-21 Distinct myeloid suppressor cell subsets correlate with plasma IL-6 and IL-10 and reduced interferon-alpha signaling in CD4+ T cells from patients with GI malignancy in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2010-08-16 A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells in MOLECULAR CANCER
  • 2010-06-25 The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity in MOLECULAR CANCER
  • 2010-04-14 Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells in BMC CANCER
  • 2009-09-23 A dose-finding and pharmacodynamic study of bortezomib in combination with weekly paclitaxel in patients with advanced solid tumors in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2009-04-26 Bortezomib pre-treatment prolongs interferon-alpha-induced STAT1 phosphorylation in melanoma cells in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2008-01-10 Activation of extracellular signaling regulated kinase in natural killer cells and monocytes following IL-2 stimulation in vitro and in patients undergoing IL-2 immunotherapy: analysis via dual parameter flow-cytometric assay in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2007-05-30 A Randomized Phase 2 Trial of Bevacizumab with or without Daily Low-Dose Interferon Alfa-2b in Metastatic Malignant Melanoma in ANNALS OF SURGICAL ONCOLOGY
  • 2007-05-15 STAT1-dependent and STAT1-independent gene expression in murine immune cells following stimulation with interferon-alpha in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2007 The Type I Interferon System With Emphasis on Its Role in Malignancies in CYTOKINES IN THE GENESIS AND TREATMENT OF CANCER
  • 2005-03 Release of Biologically Functional Interferon-Alpha from a Nanochannel Delivery System in BIOMEDICAL MICRODEVICES
  • 2005-01-25 Expression of STAT1 and STAT2 in malignant melanoma does not correlate with response to interferon-alpha adjuvant therapy in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2004-02 Expression of pro-angiogenic factors in malignant melanoma and their regulation by low-dose interferon-α in ANNALS OF SURGICAL ONCOLOGY
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