Stefan Knapp


Ontology type: schema:Person     


Person Info

NAME

Stefan

SURNAME

Knapp

Publications in SciGraph latest 50 shown

  • 2018-12 Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation in NATURE COMMUNICATIONS
  • 2018-12 Large-scale analysis of water stability in bromodomain binding pockets with grand canonical Monte Carlo in COMMUNICATIONS CHEMISTRY
  • 2018-04 New opportunities for kinase drug repurposing and target discovery in BRITISH JOURNAL OF CANCER
  • 2018-03 Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63 in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2017-12 NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin in SCIENTIFIC REPORTS
  • 2017-12 DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain in SCIENTIFIC REPORTS
  • 2017-09-27 Corrigendum: Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer in NATURE COMMUNICATIONS
  • 2017-06-30 Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer in NATURE COMMUNICATIONS
  • 2017-05-15 Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors in ONCOGENESIS
  • 2017-01 The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer in ONCOGENE
  • 2016-12 Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization in CELL DEATH & DIFFERENTIATION
  • 2016-08 Epigenomic regulation of oncogenesis by chromatin remodeling in ONCOGENE
  • 2016-07 Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk in NATURE CHEMICAL BIOLOGY
  • 2016-01 Comprehensive characterization of the Published Kinase Inhibitor Set in NATURE BIOTECHNOLOGY
  • 2015-11 The ins and outs of selective kinase inhibitor development in NATURE CHEMICAL BIOLOGY
  • 2015-11 Corrigendum: The promise and peril of chemical probes in NATURE CHEMICAL BIOLOGY
  • 2015-10 Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2015-08 The promise and peril of chemical probes in NATURE CHEMICAL BIOLOGY
  • 2015-08 Probing the epigenome in NATURE CHEMICAL BIOLOGY
  • 2015-03 Preclinical target validation using patient-derived cells in NATURE REVIEWS DRUG DISCOVERY
  • 2015 Emerging Target Families: Intractable Targets in NEW APPROACHES TO DRUG DISCOVERY
  • 2015 Genome-Wide Profiling of Molecular Recognition of Histone PTMs in HISTONE RECOGNITION
  • 2014-12 Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching in EPIGENETICS & CHROMATIN
  • 2014-10 A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics in NATURE CHEMICAL BIOLOGY
  • 2014-08 Corrigendum: Dual kinase-bromodomain inhibitors for rationally designed polypharmacology in NATURE CHEMICAL BIOLOGY
  • 2014-05 Copper is required for oncogenic BRAF signalling and tumorigenesis in NATURE
  • 2014-05 Targeting bromodomains: epigenetic readers of lysine acetylation in NATURE REVIEWS DRUG DISCOVERY
  • 2014-04-02 Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy in NATURE
  • 2014-04 Dual kinase-bromodomain inhibitors for rationally designed polypharmacology in NATURE CHEMICAL BIOLOGY
  • 2014 Selective Inhibition of Acetyl-Lysine Effector Domains of the Bromodomain Family in Oncology in NUCLEAR SIGNALING PATHWAYS AND TARGETING TRANSCRIPTION IN CANCER
  • 2014 Structural Genomics and Drug Discovery for Chromatin-Related Protein Complexes Involved in Histone Tail Recognition in SYSTEMS ANALYSIS OF CHROMATIN-RELATED PROTEIN COMPLEXES IN CANCER
  • 2013-10 Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1 in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2013-07 BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia in BLOOD CANCER JOURNAL
  • 2013-01 A public-private partnership to unlock the untargeted kinome in NATURE CHEMICAL BIOLOGY
  • 2012-11 Fragment screening of cyclin G-associated kinase by weak affinity chromatography in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2012-07 PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma in BRITISH JOURNAL OF CANCER
  • 2011-08-25 Kinase Inhibitor Selectivity Profiling Using Differential Scanning Fluorimetry in KINASE INHIBITORS
  • 2010-12 Selective inhibition of BET bromodomains in NATURE
  • 2010-05 Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function in NATURE CHEMICAL BIOLOGY
  • 2010-03 The (un)targeted cancer kinome in NATURE CHEMICAL BIOLOGY
  • 2009-12 Conformational stability and activity of p73 require a second helix in the tetramerization domain in CELL DEATH & DIFFERENTIATION
  • 2009-06 Targeting group II PAKs in cancer and metastasis in CANCER AND METASTASIS REVIEWS
  • 2008-02 Protein production and purification in NATURE METHODS
  • 2007-09 The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins in JOURNAL OF STRUCTURAL AND FUNCTIONAL GENOMICS
  • 2007-06 Protein–protein interaction site mapping using NMR-detected mutational scanning in JOURNAL OF BIOMOLECULAR NMR
  • 1999-08 Extrinsic protein stabilization by the naturally occurring osmolytes β-hydroxyectoine and betaine in EXTREMOPHILES
  • 1998-07 Architecture of nonspecific protein–DNA interactions in the Sso7d–DNA complex in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1994-11 Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus in NATURE STRUCTURAL & MOLECULAR BIOLOGY
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