David T Scadden

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David T



Publications in SciGraph latest 50 shown

  • 2018-12 dropEst: pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments in GENOME BIOLOGY
  • 2018-12 The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow in NATURE COMMUNICATIONS
  • 2017-01 Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease in NATURE MEDICINE
  • 2016-10-26 Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment in NATURE
  • 2016-10 Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis in NATURE
  • 2016-06-06 Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin in NATURE BIOTECHNOLOGY
  • 2016-04 Distinct bone marrow blood vessels differentially regulate haematopoiesis in NATURE
  • 2015-10 Engineering pulmonary vasculature in decellularized rat and human lungs in NATURE BIOTECHNOLOGY
  • 2014-10 Blood loses it when nerves go bad in CELL RESEARCH
  • 2014-07 Bayesian approach to single-cell differential expression analysis in NATURE METHODS
  • 2014-04 Bone's dark side: mutated osteoblasts implicated in leukemia in CELL RESEARCH
  • 2014-03-02 Direct measurement of local oxygen concentration in the bone marrow of live animals in NATURE
  • 2014-01 The bone marrow niche for haematopoietic stem cells in NATURE
  • 2013-12 Niche-based screening identifies small-molecule inhibitors of leukemia stem cells in NATURE CHEMICAL BIOLOGY
  • 2013-11 Differential regulation of myeloid leukemias by the bone marrow microenvironment in NATURE MEDICINE
  • 2013-07 The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity in CELL DEATH & DISEASE
  • 2013-03 Differential stem- and progenitor-cell trafficking by prostaglandin E2 in NATURE
  • 2012-06 The secrets of the bone marrow niche: Metabolic priming for AML in NATURE MEDICINE
  • 2012-01 The bone marrow at the crossroads of blood and immunity in NATURE REVIEWS IMMUNOLOGY
  • 2011-08 The Lkb1 metabolic sensor maintains haematopoietic stem cell survival in NATURE
  • 2011-07 A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function in LEUKEMIA
  • 2011-06 In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche in NATURE
  • 2011-01 In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow in NATURE PROTOCOLS
  • 2010-12 The Lkb1 metabolic sensor maintains haematopoietic stem cell survival in NATURE
  • 2010-10 HAART and response to therapy improve quality of life (QOL) of African patients with advanced HIV-associated Kaposi’s sarcoma (HIV-KS): a prospective analysis of QOL in the KAART trial in INFECTIOUS AGENTS AND CANCER
  • 2010-10 The KAART Trial: a randomized controlled trial of HAART compared to the combination of HAART and \chemotherapy in treatment-naïve patients with HIV-associated Kaposi sarcoma (HIV-KS) in KwaZulu-Natal (KZN), South Africa in INFECTIOUS AGENTS AND CANCER
  • 2010-08 Mesenchymal and haematopoietic stem cells form a unique bone marrow niche in NATURE
  • 2010-04 Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia in NATURE
  • 2010 Adult Stem Cels and Their Niches in THE CELL BIOLOGY OF STEM CELLS
  • 2009-05 Haematopoietic stem cells depend on Gαs-mediated signalling to engraft bone marrow in NATURE
  • 2009-05 Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma in LEUKEMIA
  • 2009-01 Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche in NATURE
  • 2008-02 Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation in NATURE REVIEWS GENETICS
  • 2008-02 Corrigendum: Therapeutic targeting of a stem cell niche in NATURE BIOTECHNOLOGY
  • 2008-01 A niche opportunity for stem cell therapeutics in GENE THERAPY
  • 2008 Flow Electroporation with Pulsed Electric Fields for Purging Tumor Cells in ELECTROPORATION PROTOCOLS
  • 2007-08 Corrigendum: Therapeutic targeting of a stem cell niche in NATURE BIOTECHNOLOGY
  • 2007-04 A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood in NATURE PROTOCOLS
  • 2007-03 Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo in NATURE BIOTECHNOLOGY
  • 2007-02 Therapeutic targeting of a stem cell niche in NATURE BIOTECHNOLOGY
  • 2006-09 Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a in NATURE
  • 2006-06 The stem-cell niche as an entity of action in NATURE
  • 2006-06 Osteoclasts eat stem cells out of house and home in NATURE MEDICINE
  • 2006-05 Stem cells: Good, bad and reformable in NATURE
  • 2006-04 The hematopoietic stem cell in its place in NATURE IMMUNOLOGY
  • 2006-02 Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor in NATURE
  • 2006 Cancer in the Immunosuppressed Patient in ONCOLOGY
  • 2005-10 Silencing p21Waf1/Cip1/Sdi1 expression increases gene transduction efficiency in primitive human hematopoietic cells in GENE THERAPY
  • 2005-06 In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment in NATURE
  • 2005-06 Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo in NATURE MEDICINE
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