Emad S Alnemri

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Emad S



Publications in SciGraph latest 50 shown

  • 2018-12 SUMO-mediated regulation of NLRP3 modulates inflammasome activity in NATURE COMMUNICATIONS
  • 2018-12 The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes in SCIENTIFIC REPORTS
  • 2018-06 Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis in CELL DEATH & DISEASE
  • 2018-03 Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 in CELL DEATH & DIFFERENTIATION
  • 2017-01-03 Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death in NATURE COMMUNICATIONS
  • 2015-12 Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3 in NATURE COMMUNICATIONS
  • 2015-07 Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4 in IMMUNOLOGY AND CELL BIOLOGY
  • 2015-03 The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease in NATURE MEDICINE
  • 2015-01 Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 in CELL DEATH & DIFFERENTIATION
  • 2014-12 IKKα negatively regulates ASC-dependent inflammasome activation in NATURE COMMUNICATIONS
  • 2013-02 Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging in CELL DEATH & DIFFERENTIATION
  • 2012-12 Translation termination factor eRF3 is targeted for caspase-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis in APOPTOSIS
  • 2012-01 Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 in CELL DEATH & DIFFERENTIATION
  • 2010-09 Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes in JOURNAL OF CLINICAL IMMUNOLOGY
  • 2010-07 Sensing Cytoplasmic Danger Signals by the Inflammasome in JOURNAL OF CLINICAL IMMUNOLOGY
  • 2010-05 The AIM2 inflammasome is critical for innate immunity to Francisella tularensis in NATURE IMMUNOLOGY
  • 2009-08 Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes in CELL DEATH & DIFFERENTIATION
  • 2009-03-26 AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA in NATURE
  • 2009-01 X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility in NATURE CELL BIOLOGY
  • 2009-01 Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 in CELL DEATH & DIFFERENTIATION
  • 2008-12 X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility in NATURE CELL BIOLOGY
  • 2008-06 The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila in CELL DEATH & DIFFERENTIATION
  • 2007-11 HtrA2 and Parkinson's disease: think PINK? in NATURE CELL BIOLOGY
  • 2007-09 The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation in CELL DEATH & DIFFERENTIATION
  • 2006-02 Cryopyrin and pyrin activate caspase-1, but not NF-κB, via ASC oligomerization in CELL DEATH & DIFFERENTIATION
  • 2004-08 Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils in CELL DEATH & DIFFERENTIATION
  • 2004-05 Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms in NATURE
  • 2004-02 Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis in CELL DEATH & DIFFERENTIATION
  • 2003-10 Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice in NATURE
  • 2003-08 Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1 in CELL DEATH & DIFFERENTIATION
  • 2003-03 Role of Smac in human leukaemic cell apoptosis and proliferation in ONCOGENE
  • 2003-02 FLIP is expressed in mouse testis and protects germ cells from apoptosis in CELL DEATH & DIFFERENTIATION
  • 2003 NF-κB Activation by Card Proteins in NUCLEAR FACTOR КB
  • 2002-09 Expression and transcriptional regulation of caspase-14 in simple and complex epithelia in CELL DEATH & DIFFERENTIATION
  • 2002-06-01 Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2002-04 Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC in CELL DEATH & DIFFERENTIATION
  • 2002 Control of apoptosis by using small molecule regulators of Bcl-2 family proteins in PEPTIDES FOR THE NEW MILLENNIUM
  • 2002-01 The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity in CELL DEATH & DIFFERENTIATION
  • 2001-08 Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis in ONCOGENE
  • 2001-06 Regulation of IL-1β generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins in CELL DEATH & DIFFERENTIATION
  • 2001-06 correction: A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis in NATURE
  • 2001-03 A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis in NATURE
  • 2000-08 Negative regulation of the Apaf-1 apoptosome by Hsp70 in NATURE CELL BIOLOGY
  • 1999-09 Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1 in NATURE
  • 1999-06 Hidden powers of the mitochondria in NATURE CELL BIOLOGY
  • 1999-06 Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1 in NATURE
  • 1998-12 Calpain activation is upstream of caspases in radiation-induced apoptosis in CELL DEATH & DIFFERENTIATION
  • 1997-10 Apoptosis in human monocytic THP.1 cells involves several distinct targets of N-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) in CELL DEATH & DIFFERENTIATION
  • 1990-04 Amino acid sequences of stomach and nonstomach lysozymes of ruminants in JOURNAL OF MOLECULAR EVOLUTION
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