Bernhard Klaus Keppler


Ontology type: schema:Person     


Person Info

NAME

Bernhard Klaus

SURNAME

Keppler

Publications in SciGraph latest 50 shown

  • 2022-04-06 A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance in COMMUNICATIONS CHEMISTRY
  • 2022-03-03 Solution speciation and human serum protein binding of indium(III) complexes of 8-hydroxyquinoline, deferiprone and maltol in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2022-02-21 Versatile analytical methodology for evaluation of drug-like properties of potentially multi-targeting anticancer metallodrugs in ANALYTICAL SCIENCES
  • 2021-10-12 Current and emerging mass spectrometry methods for the preclinical development of metal-based drugs: a critical appraisal in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2021-10-06 KP772 overcomes multiple drug resistance in malignant lymphoma and leukemia cells in vitro by inducing Bcl-2-independent apoptosis and upregulation of Harakiri in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2021-08-28 Estrone–salicylaldehyde N-methylated thiosemicarbazone hybrids and their copper complexes: solution structure, stability and anticancer activity in tumour spheroids in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2021-07-29 Morpho‐metabotyping the oxidative stress response in SCIENTIFIC REPORTS
  • 2021-05-05 Micro-droplet-based calibration for quantitative elemental bioimaging by LA-ICPMS in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2020-03-19 Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2018-11-21 Biological activity of PtIV prodrugs triggered by riboflavin-mediated bioorthogonal photocatalysis in SCIENTIFIC REPORTS
  • 2018-10-15 The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition in CELL DEATH & DISEASE
  • 2018-08-29 Critical assessment of different methods for quantitative measurement of metallodrug-protein associations in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2018-08-25 Serum-binding properties of isosteric ruthenium and osmium anticancer agents elucidated by SEC–ICP–MS in MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY
  • 2018-07-25 Understanding the interactions of diruthenium anticancer agents with amino acids in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2018-02-23 Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2017-04-12 EGFR-targeting peptide-coupled platinum(IV) complexes in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2017-04-12 Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2017-01-23 Electronic State of Sodium trans-[Tetrachloridobis(1H-indazole)ruthenate(III)] (NKP-1339) in Tumor, Liver and Kidney Tissue of a SW480-bearing Mouse in SCIENTIFIC REPORTS
  • 2016-03-18 Molecular mode of action of NKP-1339 – a clinically investigated ruthenium-based drug – involves ER- and ROS-related effects in colon carcinoma cell lines in INVESTIGATIONAL NEW DRUGS
  • 2016-03-09 Biological properties of novel ruthenium- and osmium-nitrosyl complexes with azole heterocycles in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2015-06-21 Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs in INVESTIGATIONAL NEW DRUGS
  • 2014-11-27 Extraction of natural radionuclides from aqueous solutions by novel maltolate-based task-specific ionic liquids in JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • 2014-11-21 Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2014-11-15 Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2014-06-24 Modulation of Activity of Known Cytotoxic Ruthenium(III) Compound (KP418) with Hampered Transmembrane Transport in Electrochemotherapy In Vitro and In Vivo in THE JOURNAL OF MEMBRANE BIOLOGY
  • 2013-04-26 A systematic capillary electrophoresis study on the effect of the buffer composition on the reactivity of the anticancer drug cisplatin to the DNA model 2′-deoxyguanosine 5′-monophosphate (dGMP) in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2013-01-26 Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2013 Osmium Complexes with Azole Heterocycles as Potential Antitumor Drugs in ENCYCLOPEDIA OF METALLOPROTEINS
  • 2012-10-18 Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2012-09-17 NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer in BMC PHARMACOLOGY AND TOXICOLOGY
  • 2012-03-29 Effect of reactivity on cellular accumulation and cytotoxicity of oxaliplatin analogues in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2012-01-07 Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2011-12-22 Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2011-11-08 Fragmentation methods on the balance: unambiguous top–down mass spectrometric characterization of oxaliplatin–ubiquitin binding sites in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2011-06-26 Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019 in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2011-06-10 A polymer inclusion membrane based on the ionic liquid trihexyl(tetradecyl)phosphonium chloride and PVC for solid–liquid extraction of Zn(II) from hydrochloric acid solution in MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY
  • 2010-11-16 α-N-Heterocyclic thiosemicarbazones induce ER stress-mediated CHOP activation in BMC PHARMACOLOGY
  • 2010-04-06 Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2010-03-11 Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339 in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2010-03-07 Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2005-03-11 Synthesis, Cytotoxicity, and Structure-Activity Relationships of New Oxaliplatin Derivatives in MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY
  • 2004-11-15 On the Coordination Properties of New Bicyclophosphite-Carbohydrates in MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY
  • 2001-03-28 Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium(III) in cell-free media in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2001-03 Hydrolysis of the tumor-inhibiting ruthenium(III) complexes HIm trans-[RuCl4(im)2] and HInd trans-[RuCl4(ind)2] investigated by means of HPCE and HPLC-MS in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 1999 Non-Platinum Antitumor Compounds in METALLOPHARMACEUTICALS I
  • 1997-08 Synthesis of water-soluble ruthenium porphyrins as DNA cleavers and potential cytotoxic agents in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 1996 Overview of Tumor-Inhibiting Non-Platinum Compounds in PLATINUM AND OTHER METAL COORDINATION COMPOUNDS IN CANCER CHEMOTHERAPY 2
  • 1992-03 Antineoplastic activity of three ruthenium derivatives against chemically induced colorectal carcinoma in rats in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 1992 Diagnostics and Experimental Therapy in CURRENT CANCER RESEARCH 1992
  • 1989 Clinical Studies with Budotitane — A New Non-Platinum Metal Complex for Cancer Therapy in RUTHENIUM AND OTHER NON-PLATINUM METAL COMPLEXES IN CANCER CHEMOTHERAPY
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