Ralph J Deberardinis

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Ralph J



Publications in SciGraph latest 50 shown

  • 2018-12 Lkb1 deficiency confers glutamine dependency in polycystic kidney disease in NATURE COMMUNICATIONS
  • 2018-05 Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis in NATURE MEDICINE
  • 2018-03 Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 in CELL DEATH & DIFFERENTIATION
  • 2018-03 RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells in NATURE CELL BIOLOGY
  • 2017-12 Genomic regression analysis of coordinated expression in NATURE COMMUNICATIONS
  • 2017-09 Ascorbate regulates haematopoietic stem cell function and leukaemogenesis in NATURE
  • 2017-09 Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism in NATURE CELL BIOLOGY
  • 2017-06 CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells in NATURE
  • 2017-06 Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation in NATURE CELL BIOLOGY
  • 2017-01 Hypoxia induces heart regeneration in adult mice in NATURE
  • 2016-12 Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine in SCIENTIFIC REPORTS
  • 2016-10 Blocking fatty acid synthesis reduces lung tumor growth in mice in NATURE MEDICINE
  • 2016-09-29 Erratum: Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma in NATURE COMMUNICATIONS
  • 2016-08-22 Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma in NATURE COMMUNICATIONS
  • 2016-04 Reductive carboxylation supports redox homeostasis during anchorage-independent growth in NATURE
  • 2016-04 Erratum: NRF2 regulates serine biosynthesis in non-small cell lung cancer in NATURE GENETICS
  • 2015-12 Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone in CANCER & METABOLISM
  • 2015-12 NRF2 regulates serine biosynthesis in non–small cell lung cancer in NATURE GENETICS
  • 2015-12 A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles in NATURE COMMUNICATIONS
  • 2015-12 D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2 in NATURE COMMUNICATIONS
  • 2015-12 Hypoxic metabolism in human hematopoietic stem cells in CELL & BIOSCIENCE
  • 2015-12 Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells in CANCER & METABOLISM
  • 2015-12 Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone in SCIENTIFIC REPORTS
  • 2015-11 Oxidative stress inhibits distant metastasis by human melanoma cells in NATURE
  • 2015-11 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling in NATURE CELL BIOLOGY
  • 2015-10 Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia in NATURE MEDICINE
  • 2015-07 Metabolic dysregulation in monogenic disorders and cancer — finding method in madness in NATURE REVIEWS CANCER
  • 2015-07 Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition in ONCOGENE
  • 2015-07 Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction in ONCOGENE
  • 2015-04 Metabolism: Growth in the fat lane in NATURE
  • 2015-04 Metabolic pathways promoting cancer cell survival and growth in NATURE CELL BIOLOGY
  • 2015-01 NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone in CELL DEATH & DISEASE
  • 2014-12 Q&A: Targeting metabolism to diagnose and treat cancer in CANCER & METABOLISM
  • 2014-05 Identifying metabolomic features that predict metastasis of melanoma from a primary site in CANCER & METABOLISM
  • 2014-05 Pyruvate dehydrogenase activity is required for optimal growth under lipid deficient conditions in CANCER & METABOLISM
  • 2014-05 Metabolic diversity in human non-small cell lung cancer in CANCER & METABOLISM
  • 2014-05 Metabolic heterogeneity in cancer in CANCER & METABOLISM
  • 2014-05 Reductive carboxylation mediated oxidative stress defense supports anchorage independent cell growth in CANCER & METABOLISM
  • 2014-03 Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells in JOURNAL OF MOLECULAR MEDICINE
  • 2014-02 A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals in NATURE MATERIALS
  • 2013-12 Metabolic changes in cancer cells upon suppression of MYC in CANCER & METABOLISM
  • 2012-10 The Hypoxic Epicardial and Subepicardial Microenvironment in JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
  • 2012-10 Erratum to: The Hypoxic Epicardial and Subepicardial Microenvironment in JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
  • 2012-09 Cancer metabolism: When more is less in NATURE
  • 2012-04 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas in NATURE MEDICINE
  • 2012-03 Good neighbours in the tumour stroma reduce oxidative stress in NATURE CELL BIOLOGY
  • 2012-01 Reductive carboxylation supports growth in tumour cells with defective mitochondria in NATURE
  • 2011-09 Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase in NATURE
  • 2011-05 Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death in ONCOGENE
  • 2011-03 Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC in NATURE REVIEWS UROLOGY
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