Lewis Clayton Cantley


Ontology type: schema:Person     


Person Info

NAME

Lewis Clayton

SURNAME

Cantley

Publications in SciGraph latest 50 shown

  • 2022-10-20 Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression in NATURE COMMUNICATIONS
  • 2022-09-09 Live cold to grow old? Thermogenesis to fight cancer in CELL RESEARCH
  • 2022-08-08 Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer in NATURE COMMUNICATIONS
  • 2022-07-28 Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models in EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • 2022-07-27 PI3K drives the de novo synthesis of coenzyme A from vitamin B5 in NATURE
  • 2022-05-25 Developing dietary interventions as therapy for cancer in NATURE REVIEWS CANCER
  • 2022-04-28 At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2022-03-31 Altered propionate metabolism contributes to tumour progression and aggressiveness in NATURE METABOLISM
  • 2022-02-18 Author Correction: Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2021-11-24 Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2021-10-08 Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis in NATURE CANCER
  • 2021-08-18 Dietary fructose improves intestinal cell survival and nutrient absorption in NATURE
  • 2021-04-01 Fatty acid synthesis is required for breast cancer brain metastasis in NATURE CANCER
  • 2021-03-24 GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase in CANCER & METABOLISM
  • 2021-01-28 Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification in NATURE COMMUNICATIONS
  • 2020-11-02 Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer in BREAST CANCER RESEARCH
  • 2020-10-30 Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer in NATURE COMMUNICATIONS
  • 2020-10-28 Identification of SARS-CoV-2 inhibitors using lung and colonic organoids in NATURE
  • 2020-09-03 Author Correction: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer in NATURE GENETICS
  • 2020-08-19 Age-induced accumulation of methylmalonic acid promotes tumour progression in NATURE
  • 2020-07-15 A ‘fast’er way to treat breast cancer in NATURE METABOLISM
  • 2020-03-03 Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer in NATURE REVIEWS ENDOCRINOLOGY
  • 2020-01-02 Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy in CANCER & METABOLISM
  • 2019-09-23 PIK3CA and MAP3K1 alterations imply luminal A status and are associated with clinical benefit from pan-PI3K inhibitor buparlisib and letrozole in ER+ metastatic breast cancer in NPJ BREAST CANCER
  • 2019-07-05 Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation in BREAST CANCER RESEARCH
  • 2019-04-09 Targeting cancer vulnerabilities with high-dose vitamin C in NATURE REVIEWS CANCER
  • 2019-03-12 Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase in SCIENTIFIC REPORTS
  • 2018-10-15 Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine in CELL DEATH & DIFFERENTIATION
  • 2018-09-21 The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation in NATURE COMMUNICATIONS
  • 2018-08-29 Publisher Correction: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors in NATURE
  • 2018-07-04 Suppression of insulin feedback enhances the efficacy of PI3K inhibitors in NATURE
  • 2018-01-17 Chromosomal instability drives metastasis through a cytosolic DNA response in NATURE
  • 2017-09-27 A Topical Report on the Design Principles of Metabolism in IMAGING AND METABOLISM
  • 2017-02-28 Genomic characteristics of trastuzumab-resistant Her2-positive metastatic breast cancer in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2016-11-04 Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death in CELL DEATH & DIFFERENTIATION
  • 2016-10-05 Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion in NATURE
  • 2016-08-25 Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer in METABOLISM IN CANCER
  • 2016-08-10 Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion in NATURE
  • 2016-06-11 PI3K-Akt-mTOR Signaling in Cancer and Cancer Therapeutics in PI3K-MTOR IN CANCER AND CANCER THERAPY
  • 2016-04-18 Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer in NATURE CELL BIOLOGY
  • 2016-03-29 Erratum: NRF2 regulates serine biosynthesis in non–small cell lung cancer in NATURE GENETICS
  • 2016-02-03 A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2 in SCIENTIFIC REPORTS
  • 2015-11-09 EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2015-10-19 NRF2 regulates serine biosynthesis in non–small cell lung cancer in NATURE GENETICS
  • 2015-10-12 Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone in CANCER & METABOLISM
  • 2015-04-13 Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer in NATURE MEDICINE
  • 2015 Diverting Glycolysis to Combat Oxidative Stress in INNOVATIVE MEDICINE
  • 2015 Computational Prediction of Protein-Protein Interactions in PROTEIN-PROTEIN INTERACTIONS
  • 2014-08-10 Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function in NATURE
  • 2014-05-28 Pancreatic cancers depend on a non-canonical glutamine metabolism pathway in CANCER & METABOLISM
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