Julian Downward

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Publications in SciGraph latest 50 shown

  • 2019-05 Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis in CELL DEATH & DIFFERENTIATION
  • 2018-12 AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons in SCIENTIFIC REPORTS
  • 2018-10 The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma in ONCOGENE
  • 2016-12 Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer in CELL DISCOVERY
  • 2016-06 Tumour-suppression function of KLF12 through regulation of anoikis in ONCOGENE
  • 2016-04-13 RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression in NATURE COMMUNICATIONS
  • 2015-07 Retraction: HMGA2 functions as a competing endogenous RNA to promote lung cancer progression in NATURE
  • 2014-11 ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1 in NATURE CELL BIOLOGY
  • 2014-09 Guidelines for the use of cell lines in biomedical research in BRITISH JOURNAL OF CANCER
  • 2014-01 HMGA2 functions as a competing endogenous RNA to promote lung cancer progression in NATURE
  • 2012-08 Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies in CELL RESEARCH
  • 2012 Assessing Cell Size and Cell Cycle Regulation in Cells with Altered TOR Activity in MTOR
  • 2011-08 An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis in ONCOGENE
  • 2011-07 PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs in ONCOGENE
  • 2011-03 Targeting RAF: trials and tribulations in NATURE MEDICINE
  • 2010-08 Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells in ONCOGENE
  • 2010-08 Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets in GENOME MEDICINE
  • 2010-06-19 Role of RAS in the Regulation of PI 3-Kinase in PHOSPHOINOSITIDE 3-KINASE IN HEALTH AND DISEASE
  • 2010-02 Rictor is a novel target of p70 S6 kinase-1 in ONCOGENE
  • 2009-12 Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells in MOLECULAR CANCER
  • 2009-11 Cancer: A tumour gene's fatal flaws in NATURE
  • 2009-08 Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin in CELL DEATH & DIFFERENTIATION
  • 2009-03 Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response in CELL DEATH & DIFFERENTIATION
  • 2008-12 Targeting RAS and PI3K in lung cancer in NATURE MEDICINE
  • 2008-10 Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer in BREAST CANCER RESEARCH
  • 2008-06 Viral pro-survival proteins block separate stages in Bax activation but changes in mitochondrial ultrastructure still occur in CELL DEATH & DIFFERENTIATION
  • 2007-12 Functional inhibition of PI3K by the βGBP molecule suppresses Ras–MAPK signalling to block cell proliferation in ONCOGENE
  • 2007-11 The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1 in NATURE CELL BIOLOGY
  • 2007-02 Upregulation of two BH3-only proteins, Bmf and Bim, during TGFβ-induced apoptosis in ONCOGENE
  • 2006-12 The protease inhibitor Ucf-101 induces cellular responses independently of its known target, HtrA2/Omi in CELL DEATH & DIFFERENTIATION
  • 2006-11 Raf plus TGFβ-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin in ONCOGENE
  • 2006-10 Minimizing the risk of reporting false positives in large-scale RNAi screens in NATURE METHODS
  • 2006-10 Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis in CELL DEATH & DIFFERENTIATION
  • 2006-02 Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling in ONCOGENE
  • 2006-01 Cancer biology: Signatures guide drug choice in NATURE
  • 2005-09 PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP in ONCOGENE
  • 2004-11 Use of RNA interference libraries to investigate oncogenic signalling in mammalian cells in ONCOGENE
  • 2004-11 RNA interference-based functional genomics in cancer research – an introduction in ONCOGENE
  • 2004-04 Role of Bim in the survival pathway induced by Raf in epithelial cells in ONCOGENE
  • 2003-11 RNAi and 2DE, a promising combination for analysis of phospho-signalling and substrate identification in INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
  • 2003-09 RNAi and 2DE, a promising combination for analysis of phospho-signalling and substrate identification in INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
  • 2003-08 Cell biology: Metabolism meets death in NATURE
  • 2003-05 c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner in CELL DEATH & DIFFERENTIATION
  • 2003-01 Targeting RAS signalling pathways in cancer therapy in NATURE REVIEWS CANCER
  • 2002-10 Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain in CELL DEATH & DIFFERENTIATION
  • 2002-08 Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway in ONCOGENE
  • 2001-08 Navigating gene expression using microarrays — a technology review in NATURE CELL BIOLOGY
  • 2001-06 The ins and outs of signalling in NATURE
  • 2001-04 Analysis of the transcriptional program induced by Raf in epithelial cells in NATURE GENETICS
  • 2000-10 The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function in ONCOGENE
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