Arlene H Sharpe

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Arlene H



Publications in SciGraph latest 50 shown

  • 2017-12 Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: a report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2017-11-13 The diverse functions of the PD1 inhibitory pathway in NATURE REVIEWS IMMUNOLOGY
  • 2017-10 Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection in NATURE IMMUNOLOGY
  • 2017-07 The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection in NATURE IMMUNOLOGY
  • 2017-07 In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target in NATURE
  • 2017 Anti-Programmed Death 1 (PD1) in CANCER THERAPEUTIC TARGETS
  • 2016-12 Suppression by TFR cells leads to durable and selective inhibition of B cell effector function in NATURE IMMUNOLOGY
  • 2016-09 Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy in NATURE
  • 2016 Enhancing the Efficacy of Checkpoint Blockade Through Combination Therapies in NOVEL IMMUNOTHERAPEUTIC APPROACHES TO THE TREATMENT OF CANCER
  • 2015-12 Core skin DC signatures control immune tolerance to skin cancer and limit anti-tumor immunity in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2015-12 The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2015-02 Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability in NATURE IMMUNOLOGY
  • 2015 In Vitro Assay to Sensitively Measure Tfr Suppressive Capacity and Tfh Stimulation of B Cell Responses in T FOLLICULAR HELPER CELLS
  • 2014-11 Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens in NATURE
  • 2014-01 GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses in NATURE IMMUNOLOGY
  • 2013-02 The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood in NATURE IMMUNOLOGY
  • 2013 Anti-Programmed Death 1 (PD1) in CANCER THERAPEUTIC TARGETS
  • 2012-07 CD28 ligation increases macrophage suppression of T-cell proliferation in CELLULAR & MOLECULAR IMMUNOLOGY
  • 2012-02 A new therapeutic strategy for malaria: targeting T cell exhaustion in NATURE IMMUNOLOGY
  • 2010-06 PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells in NATURE IMMUNOLOGY
  • 2010-02 Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells in NATURE IMMUNOLOGY
  • 2010-01 PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions in MUCOSAL IMMUNOLOGY
  • 2009-02 The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells in NATURE IMMUNOLOGY
  • 2008-09 Inside Lab Invest in LABORATORY INVESTIGATION
  • 2008-09 Intrafollicular location of marginal zone/CD1dhi B cells is associated with autoimmune pathology in a mouse model of lupus in LABORATORY INVESTIGATION
  • 2008-03 Association of LY9 in UK and Canadian SLE families in GENES & IMMUNITY
  • 2007-03 The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection in NATURE IMMUNOLOGY
  • 2006-02 Restoring function in exhausted CD8 T cells during chronic viral infection in NATURE
  • 2005-03 Dendritic cells giveth and taketh away in NATURE IMMUNOLOGY
  • 2004-12 Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity in NATURE IMMUNOLOGY
  • 2003-09 The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin in NATURE IMMUNOLOGY
  • 2003-07 The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens in NATURE IMMUNOLOGY
  • 2002-09 Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity in NATURE MEDICINE
  • 2002-08 Protect the killer: CTLs need defenses against the tumor in NATURE MEDICINE
  • 2002-02 The B7–CD28 superfamily in NATURE REVIEWS IMMUNOLOGY
  • 2001-11-13 The Role of Costimulation in T Cell Differentiation in CYTOKINES AND AUTOIMMUNE DISEASES
  • 2001-05 SAP controls T cell responses to virus and terminal differentiation of TH2 cells in NATURE IMMUNOLOGY
  • 2001-03 PD-L2 is a second ligand for PD-1 and inhibits T cell activation in NATURE IMMUNOLOGY
  • 2001-01 ICOS is critical for CD40-mediated antibody class switching in NATURE
  • 2000-03 p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours in NATURE
  • 1999-12 T-cell stimulation: an abundance of B7s in NATURE MEDICINE
  • 1999-08 Heparin is essential for the storage of specific granule proteases in mast cells in NATURE
  • 1999-04 p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development in NATURE
  • 1997-08 The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3 in MAMMALIAN GENOME
  • 1997-03 Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene in NATURE GENETICS
  • 1996 B7-Deficient Mice Reveal an Alternative Functional CTLA-4 Counterreceptor in GENETIC MODELS OF IMMUNE AND INFLAMMATORY DISEASES
  • 1996 The Regulatory Functions of Co-Stimulators Revealed in Transgenic Mice in GENETIC MODELS OF IMMUNE AND INFLAMMATORY DISEASES
  • 1995-06 Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86) in IMMUNOGENETICS
  • 1990-07 Role of abortive retroviral infection of neurons in spongiform CNS degeneration in NATURE
  • 1984 Reovirus Cytopathology: Effects on Cellular Macromolecular Synthesis and the Cytoskeleton in VIRAL CYTOPATHOLOGY
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