Marcel Kool


Ontology type: schema:Person     


Person Info

NAME

Marcel

SURNAME

Kool

Publications in SciGraph latest 50 shown

  • 2019-01 ETMR-like infantile cerebellar embryonal tumors in the extended morphologic spectrum of DICER1-related tumors in ACTA NEUROPATHOLOGICA
  • 2019-01 Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors in JOURNAL OF NEURO-ONCOLOGY
  • 2018-12 Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis in NATURE COMMUNICATIONS
  • 2018-12 Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors in NATURE COMMUNICATIONS
  • 2018-11 A biobank of patient-derived pediatric brain tumor models in NATURE MEDICINE
  • 2018-08 Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas in ACTA NEUROPATHOLOGICA
  • 2018-08 Molecular characterization of medulloblastomas with extensive nodularity (MBEN) in ACTA NEUROPATHOLOGICA
  • 2018-08 Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile in ACTA NEUROPATHOLOGICA
  • 2018-08 Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information in MODERN PATHOLOGY
  • 2018-08 Heterogeneity within the PF-EPN-B ependymoma subgroup in ACTA NEUROPATHOLOGICA
  • 2018-07 Author Correction: The landscape of genomic alterations across childhood cancers in NATURE
  • 2018-04 Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation in ACTA NEUROPATHOLOGICA
  • 2018-03 DNA methylation-based classification of central nervous system tumours in NATURE
  • 2018-01 Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling in NATURE
  • 2017-12 Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation in SCIENTIFIC REPORTS
  • 2017-12 DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma in ACTA NEUROPATHOLOGICA
  • 2017-11 Reduced histone H3 K27 trimethylation is encountered in about 50% of atypical teratoid/rhabdoid tumors (AT/RT) but is not associated with molecular subgroup status and outcome in ACTA NEUROPATHOLOGICA
  • 2017-11 Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome in ACTA NEUROPATHOLOGICA
  • 2017-10 A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors in NATURE MEDICINE
  • 2017-10 Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor in NATURE CELL BIOLOGY
  • 2017-09-14 Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells in ONCOGENE
  • 2017-07 The whole-genome landscape of medulloblastoma subtypes in NATURE
  • 2017-05 Abstracts of the 52nd Workshop for Pediatric Research in MOLECULAR AND CELLULAR PEDIATRICS
  • 2017-05 Spatial heterogeneity in medulloblastoma in NATURE GENETICS
  • 2017-02 SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors in JOURNAL OF NEURO-ONCOLOGY
  • 2017-01 The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants in ACTA NEUROPATHOLOGICA
  • 2016-12 Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2016-07 Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis in ACTA NEUROPATHOLOGICA
  • 2016-06 Risk stratification of childhood medulloblastoma in the molecular era: the current consensus in ACTA NEUROPATHOLOGICA
  • 2016-06 Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets in ACTA NEUROPATHOLOGICA
  • 2016-02 Active medulloblastoma enhancers reveal subgroup-specific cellular origins in NATURE
  • 2016-01 Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity in ACTA NEUROPATHOLOGICA
  • 2016-01 Divergent clonal selection dominates medulloblastoma at recurrence in NATURE
  • 2015-12 Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance in NATURE COMMUNICATIONS
  • 2015-12 Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2015-05 Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers in ACTA NEUROPATHOLOGICA
  • 2015-05 Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric medulloblastomas in JOURNAL OF NEURO-ONCOLOGY
  • 2015-05 Long-term survival in a case of ETANTR with histological features of neuronal maturation after therapy in VIRCHOWS ARCHIV
  • 2015-02 The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants in ONCOGENE
  • 2014-12 Identification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster in NATURE COMMUNICATIONS
  • 2014-09 The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma in NATURE MEDICINE
  • 2014-08 Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity in ACTA NEUROPATHOLOGICA
  • 2014-07 Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma in NATURE
  • 2014-07 Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort in ACTA NEUROPATHOLOGICA
  • 2014-07 Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts in ACTA NEUROPATHOLOGICA
  • 2014-06 Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing in NATURE
  • 2014-06 Subgroup-specific localization of human medulloblastoma based on pre-operative MRI in ACTA NEUROPATHOLOGICA
  • 2014-02 Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group in ACTA NEUROPATHOLOGICA
  • 2013-12 Prognostic value and functional consequences of cell cycle inhibitor p27Kip1 loss in medulloblastoma in BIOMARKER RESEARCH
  • 2013-12 TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma in ACTA NEUROPATHOLOGICA
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