Brian Kevin Park


Ontology type: schema:Person     


Person Info

NAME

Brian Kevin

SURNAME

Park

Publications in SciGraph latest 50 shown

  • 2021-09-12 Systems analysis of miRNA biomarkers to inform drug safety in ARCHIVES OF TOXICOLOGY
  • 2021-07-29 The application of cytokeratin-18 as a biomarker for drug-induced liver injury in ARCHIVES OF TOXICOLOGY
  • 2021-05-29 Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification in ARCHIVES OF TOXICOLOGY
  • 2021-02-03 Assessing technical and biological variation in SWATH-MS-based proteomic analysis of chronic lymphocytic leukaemia cells in SCIENTIFIC REPORTS
  • 2020-12-30 Retraction Note: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity in MOLECULAR MEDICINE
  • 2020-01-30 Expression of Concern to: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity in MOLECULAR MEDICINE
  • 2019-11-20 Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models in NATURE REVIEWS DRUG DISCOVERY
  • 2018-11-28 Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration in STEM CELL RESEARCH & THERAPY
  • 2018-11-13 Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury in ARCHIVES OF TOXICOLOGY
  • 2018-06-11 Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds in NPJ SYSTEMS BIOLOGY AND APPLICATIONS
  • 2018-03-21 Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing in DRUG-INDUCED LIVER TOXICITY
  • 2018-01-23 Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms in ARCHIVES OF TOXICOLOGY
  • 2017-11-22 Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity in SCIENTIFIC REPORTS
  • 2017-10-19 Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies in NPJ REGENERATIVE MEDICINE
  • 2016-09-22 Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man in ARCHIVES OF TOXICOLOGY
  • 2016-08-25 7th Drug hypersensitivity meeting: part two in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2016-08-25 7th drug hypersensitivity meeting: part one in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2016-06-25 A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity in ARCHIVES OF TOXICOLOGY
  • 2016-05-04 Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease in SCIENTIFIC REPORTS
  • 2016-04-02 Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile in ARCHIVES OF TOXICOLOGY
  • 2015-11-26 Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome in SCIENTIFIC REPORTS
  • 2015-10-22 Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury in SCIENTIFIC REPORTS
  • 2015-09-02 Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy in SCIENTIFIC REPORTS
  • 2015-08-14 Development of interferon beta-neutralising antibodies in multiple sclerosis—a systematic review and meta-analysis in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2014-07-18 Detection of interleukin-22 secreting T-cells in piperacillin hypersensitive patients with cystic fibrosis in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Negative regulation by Programmed Death Ligand-1 during drug-specific priming of T-cells and the influence of Programmed Death-1 on effector T-cell function in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Chemical modification of the 6'-amino cyclopropyl of abacavir eliminates HLA-B*57:01-restricted CD8+ T-cell activation without loss of antiviral activity in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Characterization of amoxicillin and clavulanic-acid-responsive CD4+ And CD8+ T-cells in patients with co-amoxiclav-induced liver injury in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 HLA-DQ restricted activation of nitroso-sulfamethoxazole-specific CD4+ T-lymphocytes in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Establishment of an HLA-typed cohort of 1000 healthy blood donors and use of a dendritic cell priming assay to prime naive T cells to structurally divergent drugs in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Antigen exposure required for T cell activation in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Characterization of primary human T-cell responses to p-phenylenediamine and Bandrowski's base in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Identification of susceptible HLA class II co-amoxiclav genotypes based on the analysis of drug-specific T-cells from patients with liver injury in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Characterization of Flucloxacillin-specific CD8+ T-cells in a mouse model in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Skewing of the TCR V repertoire in SMX-NO specific T cell responses in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Isoniazid-specific T-cell Responses in patients with anti-tuberculosis drug related liver injury in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Characterization of the TCR V repertoire of piperacillin-specific T-cells in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Abacavir forms novel cross-linking abacavir protein adducts in patients in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-07-18 Abs No: HLA-A*31:01 positive hypersensitive patient in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2013-10-23 T Cell Responses to Drugs and Drug Metabolites in T LYMPHOCYTES AS TOOLS IN DIAGNOSTICS AND IMMUNOTOXICOLOGY
  • 2013-08-23 Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME in ARCHIVES OF TOXICOLOGY
  • 2013-06-12 Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2013-03-28 Challenges and approaches for the development of safer immunomodulatory biologics in NATURE REVIEWS DRUG DISCOVERY
  • 2012-08-29 Immunogenicity to Biologics: Mechanisms, Prediction and Reduction in ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
  • 2012-07-25 Serum microRNA Biomarkers for Drug‐Induced Liver Injury in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2012-06-27 The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2012-06-25 In silicoanalysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers in GENOME MEDICINE
  • 2012-05-29 Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials in MOLECULAR MEDICINE
  • 2012-05 Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics in PHARMACOLOGICAL REPORTS
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