Johan H Van Es

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Johan H


Van Es

Publications in SciGraph latest 50 shown

  • 2018-08 Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient in NATURE CELL BIOLOGY
  • 2017-03 Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium in ONCOGENE
  • 2016-03-09 Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation in NATURE COMMUNICATIONS
  • 2015 Generation and Analysis of Mouse Intestinal Tumors and Organoids Harboring APC and K-Ras Mutations in MOUSE MODELS OF CANCER
  • 2014-12 A20 controls intestinal homeostasis through cell-specific activities in NATURE COMMUNICATIONS
  • 2014-01 Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny in NATURE METHODS
  • 2013-07 Loss of Tcf7 diminishes hematopoietic stem/progenitor cell function in LEUKEMIA
  • 2013-05 DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus in GENOME BIOLOGY
  • 2013-01-27 In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration in NATURE
  • 2012-12 NOTCH1 Signaling as a Therapeutic Target in Sézary Syndrome in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2012-10 Dll1+ secretory progenitor cells revert to stem cells upon crypt damage in NATURE CELL BIOLOGY
  • 2012-08 Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors in NATURE
  • 2012-01 Controlled gene expression in primary Lgr5 organoid cultures in NATURE METHODS
  • 2012-01 Single-molecule transcript counting of stem-cell markers in the mouse intestine in NATURE CELL BIOLOGY
  • 2011-08 Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling in NATURE
  • 2011-01 Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts in NATURE
  • 2010-05-17 Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors in NATURE COMMUNICATIONS
  • 2009-07 HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction in NATURE NEUROSCIENCE
  • 2009-05 Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche in NATURE
  • 2009-01 Crypt stem cells as the cells-of-origin of intestinal cancer in NATURE
  • 2008-11 Lgr5 marks cycling, yet long-lived, hair follicle stem cells in NATURE GENETICS
  • 2007-10-25 Identification of stem cells in small intestine and colon by marker gene Lgr5 in NATURE
  • 2005-06 Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells in NATURE
  • 2005-04 Wnt signalling induces maturation of Paneth cells in intestinal crypts in NATURE CELL BIOLOGY
  • 2001-04 Mutations in the APC tumour suppressor gene cause chromosomal instability in NATURE CELL BIOLOGY
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