Warren J Leonard

Ontology type: schema:Person     

Person Info


Warren J



Publications in SciGraph latest 50 shown

  • 2019-01 Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity in MUCOSAL IMMUNOLOGY
  • 2018-12 Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 in NATURE COMMUNICATIONS
  • 2018-10 Biology and regulation of IL-2: from molecular mechanisms to human therapy in NATURE REVIEWS IMMUNOLOGY
  • 2017-12 Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells in NATURE COMMUNICATIONS
  • 2017 Interleukin-21 in CANCER THERAPEUTIC TARGETS
  • 2016-12 Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice in ARTHRITIS RESEARCH & THERAPY
  • 2016-07 BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers in NATURE IMMUNOLOGY
  • 2016-05 JAK3 inhibition—is it sufficient? in NATURE CHEMICAL BIOLOGY
  • 2016-04 A molecular threshold for effector CD8+ T cell differentiation controlled by transcription factors Blimp-1 and T-bet in NATURE IMMUNOLOGY
  • 2016 Interleukin 21 in CANCER THERAPEUTIC TARGETS
  • 2015-12 IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells in NATURE COMMUNICATIONS
  • 2015-05 Erratum: The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells in NATURE IMMUNOLOGY
  • 2015-03 The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells in NATURE IMMUNOLOGY
  • 2014-08 Autoimmunity: Regulatory B cells—IL-35 and IL-21 regulate the regulators in NATURE REVIEWS RHEUMATOLOGY
  • 2014-05 Interleukin-21: a double-edged sword with therapeutic potential in NATURE REVIEWS DRUG DISCOVERY
  • 2014 Interleukin-21: A Pleiotropic Mediator of Immunity and Inflammation with Broad Therapeutic Potential in CYTOKINE FRONTIERS
  • 2012-12 Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15 in NATURE IMMUNOLOGY
  • 2012-11 Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions in NATURE
  • 2012-09-19 Compensatory dendritic cell development mediated by BATF–IRF interactions in NATURE
  • 2012-09-19 BATF–JUN is critical for IRF4-mediated transcription in T cells in NATURE
  • 2011-12 Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells in BONE MARROW TRANSPLANTATION
  • 2011-06 Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages in NATURE IMMUNOLOGY
  • 2011-06 Role of Thymic Stromal Lymphopoietin (TSLP) in Palifermin-Mediated Immune Modulation and Protection from Acute Murine Graft-Versus-Host Disease in JOURNAL OF CLINICAL IMMUNOLOGY
  • 2010-04 IL-21 is critical for GVHD in a mouse model in BONE MARROW TRANSPLANTATION
  • 2010-01 NetPath: a public resource of curated signal transduction pathways in GENOME BIOLOGY
  • 2009-07 New insights into the regulation of T cells by γc family cytokines in NATURE REVIEWS IMMUNOLOGY
  • 2008-11 Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression in NATURE IMMUNOLOGY
  • 2007-09 IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways in NATURE IMMUNOLOGY
  • 2006-10 Overexpression of Interleukin 21 Induces Expansion of Hematopoietic Progenitor Cells in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2005-09 Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation in NATURE REVIEWS IMMUNOLOGY
  • 2004-11 Interleukin-7 deficiency in rheumatoid arthritis in ARTHRITIS RESEARCH & THERAPY
  • 2004-10 GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells in NATURE IMMUNOLOGY
  • 2003-09 Immune deficiencies due to defects in cytokine signaling in CURRENT ALLERGY AND ASTHMA REPORTS
  • 2003 Mechanisms and Biological Consequences of STAT Signaling by Cytokines that Share the Common Cytokine Receptor γ Chain, γc in SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION (STATS)
  • 2002-07 TSLP: finally in the limelight in NATURE IMMUNOLOGY
  • 2002 The JAK-STAT Pathway in HORMONE SIGNALING
  • 2001-12 Cytokines and immunodeficiency diseases in NATURE REVIEWS IMMUNOLOGY
  • 2001-04 Role of Jak Kinases and STATs in Cytokine Signal Transduction in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2000-07 Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin in NATURE IMMUNOLOGY
  • 2000-05 The role of Stat5a and Stat5b in signaling by IL-2 family cytokines in ONCOGENE
  • 1998-12 Defective IL7R expression in T-B+NK + severe combined immunodeficiency in NATURE GENETICS
  • 1996-09 STATs and cytokine specificity in NATURE MEDICINE
  • 1995-11 Genetic mapping of the interleukin 2 receptor alpha and beta chain genes in the mouse in MAMMALIAN GENOME
  • 1994-05 Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling in NATURE
  • 1994 Sharing of a Common γ Chain, γc, by the IL-2, IL-4, and IL-7 Receptors: Implications for X-Linked Severe Combined Immunodeficiency (XSCID) in MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION V
  • 1987 Workshop Summary: Interleukin 2 in MOLECULAR BASIS OF LYMPHOKINE ACTION
  • 1987 Identification of a Novel Interleukin-2 Receptor Subunit in MOLECULAR BASIS OF LYMPHOKINE ACTION
  • 1985 Interleukin-2 Receptors in HUMAN T CELL CLONES
  • 1985 Molecular Analysis of the Human Interleukin-2 Receptor in LYMPHOPROLIFERATIVE DISEASES: PATHOGENESIS, DIAGNOSIS, THERAPY
  • 1985 Molecular Cloning and Expression of cDNAS Encoding the Human Interleukin-2 Receptor in IMMUNE REGULATION
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "affiliation": [
            "affiliation": {
              "id": "https://www.grid.ac/institutes/grid.279885.9", 
              "type": "Organization"
            "isCurrent": true, 
            "type": "OrganizationRole"
            "id": "https://www.grid.ac/institutes/grid.280128.1", 
            "type": "Organization"
            "id": "https://www.grid.ac/institutes/grid.420086.8", 
            "type": "Organization"
            "id": "https://www.grid.ac/institutes/grid.417738.e", 
            "type": "Organization"
            "id": "https://www.grid.ac/institutes/grid.94365.3d", 
            "type": "Organization"
            "id": "https://www.grid.ac/institutes/grid.497530.c", 
            "type": "Organization"
            "id": "https://www.grid.ac/institutes/grid.266102.1", 
            "type": "Organization"
            "id": "https://www.grid.ac/institutes/grid.410781.b", 
            "type": "Organization"
            "id": "https://www.grid.ac/institutes/grid.239552.a", 
            "type": "Organization"
            "id": "https://www.grid.ac/institutes/grid.420089.7", 
            "type": "Organization"
        "familyName": "Leonard", 
        "givenName": "Warren J", 
        "id": "sg:person.01052534741.63", 
        "identifier": {
          "name": "orcid_id", 
          "type": "PropertyValue", 
          "value": [
        "sameAs": [
        "sdDataset": "persons", 
        "sdDatePublished": "2019-03-07T14:49", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        "sdSource": "s3://com-uberresearch-data-dimensions-researchers-20181010/20181011/dim_researchers/base/researchers_546.json", 
        "type": "Person"

    Download the RDF metadata as:  json-ld nt turtle xml License info


    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/person.01052534741.63'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/person.01052534741.63'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/person.01052534741.63'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/person.01052534741.63'


    This table displays all metadata directly associated to this object as RDF triples.

    39 TRIPLES      11 PREDICATES      22 URIs      8 LITERALS      3 BLANK NODES

    Subject Predicate Object
    1 sg:person.01052534741.63 schema:affiliation N907658c7414e41c7b111525129133b02
    2 https://www.grid.ac/institutes/grid.239552.a
    3 https://www.grid.ac/institutes/grid.266102.1
    4 https://www.grid.ac/institutes/grid.280128.1
    5 https://www.grid.ac/institutes/grid.410781.b
    6 https://www.grid.ac/institutes/grid.417738.e
    7 https://www.grid.ac/institutes/grid.420086.8
    8 https://www.grid.ac/institutes/grid.420089.7
    9 https://www.grid.ac/institutes/grid.497530.c
    10 https://www.grid.ac/institutes/grid.94365.3d
    11 schema:familyName Leonard
    12 schema:givenName Warren J
    13 schema:identifier N9fe59c21610e42b4a44eefbb10f558bf
    14 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052534741.63
    15 https://orcid.org/0000-0002-5740-7448
    16 schema:sdDatePublished 2019-03-07T14:49
    17 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    18 schema:sdPublisher Ncfb8c5b9073641c98bcca6474022f8d9
    19 sgo:license sg:explorer/license/
    20 sgo:sdDataset persons
    21 rdf:type schema:Person
    22 N907658c7414e41c7b111525129133b02 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
    23 sgo:isCurrent true
    24 rdf:type schema:OrganizationRole
    25 N9fe59c21610e42b4a44eefbb10f558bf schema:name orcid_id
    26 schema:value 0000-0002-5740-7448
    27 rdf:type schema:PropertyValue
    28 Ncfb8c5b9073641c98bcca6474022f8d9 schema:name Springer Nature - SN SciGraph project
    29 rdf:type schema:Organization
    30 https://www.grid.ac/institutes/grid.239552.a schema:Organization
    31 https://www.grid.ac/institutes/grid.266102.1 schema:Organization
    32 https://www.grid.ac/institutes/grid.279885.9 schema:Organization
    33 https://www.grid.ac/institutes/grid.280128.1 schema:Organization
    34 https://www.grid.ac/institutes/grid.410781.b schema:Organization
    35 https://www.grid.ac/institutes/grid.417738.e schema:Organization
    36 https://www.grid.ac/institutes/grid.420086.8 schema:Organization
    37 https://www.grid.ac/institutes/grid.420089.7 schema:Organization
    38 https://www.grid.ac/institutes/grid.497530.c schema:Organization
    39 https://www.grid.ac/institutes/grid.94365.3d schema:Organization

    Preview window. Press ESC to close (or click here)