Methods And Compositions For Reprogramming Müller Glia


Ontology type: sgo:Patent     


Patent Info

DATE

2020-12-03T00:00

AUTHORS

REH THOMAS , JORSTAD NIKOLAS , TODD LEVI

ABSTRACT

Nucleic acid molecules and compositions, and methods using the same are provided herein for intraocular gene-based delivery and expression of two or more proneural bHLH transcription factors in the retina. The nucleic acid molecules, compositions and methods disclosed herein stimulate regeneration of retinal interneurons from retinal Müller glia (MG) and reprogram the MG into bipolar, amacrine, horizontal, and/or ganglion cells. Such methods and nucleic acid molecules are used for vision restoration and/or treatment of a range of ocular diseases involving retinal degeneration after injury, disease, or vison loss. More... »

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "REH THOMAS", 
        "type": "Person"
      }, 
      {
        "name": "JORSTAD NIKOLAS", 
        "type": "Person"
      }, 
      {
        "name": "TODD LEVI", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature23283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090896494", 
          "https://doi.org/10.1038/nature23283"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-12-03T00:00", 
    "description": "

Nucleic acid molecules and compositions, and methods using the same are provided herein for intraocular gene-based delivery and expression of two or more proneural bHLH transcription factors in the retina. The nucleic acid molecules, compositions and methods disclosed herein stimulate regeneration of retinal interneurons from retinal Müller glia (MG) and reprogram the MG into bipolar, amacrine, horizontal, and/or ganglion cells. Such methods and nucleic acid molecules are used for vision restoration and/or treatment of a range of ocular diseases involving retinal degeneration after injury, disease, or vison loss.

", "id": "sg:patent.WO-2020223308-A3", "name": "METHODS AND COMPOSITIONS FOR REPROGRAMMING M\u00dcLLER GLIA", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.34477.33", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/WO-2020223308-A3" ], "sdDataset": "patents", "sdDatePublished": "2022-05-10T11:02", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/patent/patent_5.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.WO-2020223308-A3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.WO-2020223308-A3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.WO-2020223308-A3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.WO-2020223308-A3'


 

This table displays all metadata directly associated to this object as RDF triples.

37 TRIPLES      14 PREDICATES      16 URIs      8 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.WO-2020223308-A3 schema:about anzsrc-for:11
2 anzsrc-for:1113
3 schema:author Nfb8b93218dc24068b6c515f0b00f49fd
4 schema:citation sg:pub.10.1038/nature23283
5 schema:datePublished 2020-12-03T00:00
6 schema:description <p num="0000">Nucleic acid molecules and compositions, and methods using the same are provided herein for intraocular gene-based delivery and expression of two or more proneural bHLH transcription factors in the retina. The nucleic acid molecules, compositions and methods disclosed herein stimulate regeneration of retinal interneurons from retinal M&#252;ller glia (MG) and reprogram the MG into bipolar, amacrine, horizontal, and/or ganglion cells. Such methods and nucleic acid molecules are used for vision restoration and/or treatment of a range of ocular diseases involving retinal degeneration after injury, disease, or vison loss.</p>
7 schema:name METHODS AND COMPOSITIONS FOR REPROGRAMMING MÜLLER GLIA
8 schema:recipient grid-institutes:grid.34477.33
9 schema:sameAs https://app.dimensions.ai/details/patent/WO-2020223308-A3
10 schema:sdDatePublished 2022-05-10T11:02
11 schema:sdLicense https://scigraph.springernature.com/explorer/license/
12 schema:sdPublisher Nc06e0f83d9d94c17b2de133c33ce4187
13 sgo:license sg:explorer/license/
14 sgo:sdDataset patents
15 rdf:type sgo:Patent
16 N3aa35bd229fb4af4a4171a2bdb1499b7 rdf:first Nf14f926608ef47c294e33e9e81355106
17 rdf:rest rdf:nil
18 N4cb743c668264b91ae3b525c4742072b schema:name REH THOMAS
19 rdf:type schema:Person
20 Nc06e0f83d9d94c17b2de133c33ce4187 schema:name Springer Nature - SN SciGraph project
21 rdf:type schema:Organization
22 Nc96dd1c429da48ceb8eb0696d166f6d8 schema:name JORSTAD NIKOLAS
23 rdf:type schema:Person
24 Nd29c0270e6e34b37aadc713151e3ef4c rdf:first Nc96dd1c429da48ceb8eb0696d166f6d8
25 rdf:rest N3aa35bd229fb4af4a4171a2bdb1499b7
26 Nf14f926608ef47c294e33e9e81355106 schema:name TODD LEVI
27 rdf:type schema:Person
28 Nfb8b93218dc24068b6c515f0b00f49fd rdf:first N4cb743c668264b91ae3b525c4742072b
29 rdf:rest Nd29c0270e6e34b37aadc713151e3ef4c
30 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
31 rdf:type schema:DefinedTerm
32 anzsrc-for:1113 schema:inDefinedTermSet anzsrc-for:
33 rdf:type schema:DefinedTerm
34 sg:pub.10.1038/nature23283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090896494
35 https://doi.org/10.1038/nature23283
36 rdf:type schema:CreativeWork
37 grid-institutes:grid.34477.33 schema:Organization
 




Preview window. Press ESC to close (or click here)


...