System For Genome Editing


Ontology type: sgo:Patent     


Patent Info

DATE

2020-10-15T00:00

AUTHORS

LIU DAVID , NELSON JAMES

ABSTRACT

The present specification provides compositions and methods that are capable of directly installing an insertion or deletion of a given nucleotide at a specified genetic locus. The compositions and methods involve the novel combination of the use an engineered RNA enzyme (i.e., ''ribozyme'') that is capable of site-specifically inserting or deleting a single nucleotide at a genetic locus and the use of a nucleic acid programmable DNA binding protein (napDNAbp) (e.g., Cas9) to target the engineered ribozyme to a specified genetic locus, thereby allowing for the direct installation of an insertion of deletion at the specified genetic locus by the engineered ribozyme. More... »

Related SciGraph Publications

  • 2017-06-06. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery in NATURE COMMUNICATIONS
  • 2016-04-20. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage in NATURE
  • 2018-05-15. The CRISPR tool kit for genome editing and beyond in NATURE COMMUNICATIONS
  • 2013-10-24. Genome engineering using the CRISPR-Cas9 system in NATURE PROTOCOLS
  • 2009-08-25. Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements in BIOLOGY DIRECT
  • 2015-03-23. Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining in NATURE BIOTECHNOLOGY
  • 2015-03-24. Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells in NATURE BIOTECHNOLOGY
  • 2017-05-01. CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets in NATURE METHODS
  • 2013-08-01. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering in NATURE BIOTECHNOLOGY
  • 2016-01-06. High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects in NATURE
  • 2014-12-16. GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases in NATURE BIOTECHNOLOGY
  • 2015-11-02. Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition in NATURE BIOTECHNOLOGY
  • 2006-11-26. Post-translational enzyme activation in an animal via optimized conditional protein splicing in NATURE CHEMICAL BIOLOGY
  • 2019-02-04. CasX enzymes comprise a distinct family of RNA-guided genome editors in NATURE
  • 2015-06-22. Engineered CRISPR-Cas9 nucleases with altered PAM specificities in NATURE
  • 2015-02-05. Therapeutic genome editing: prospects and challenges in NATURE MEDICINE
  • 2016-01-20. Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA in NATURE BIOTECHNOLOGY
  • 2018-02-28. Evolved Cas9 variants with broad PAM compatibility and high DNA specificity in NATURE
  • 2017-03-27. The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies in HUMAN GENETICS
  • 1994-10. Ribozyme-mediated repair of defective mRNA by targeted trans-splicing in NATURE
  • 2015-06-01. Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display in NATURE METHODS
  • 2011-03-30. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III in NATURE
  • 2018-07-16. Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements in NATURE BIOTECHNOLOGY
  • 2018-06-11. CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response in NATURE MEDICINE
  • 1997-02-13. PCNA: structure, functions and interactions in ONCOGENE
  • 2016-09-26. Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection in NATURE
  • 2016-05-02. Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2017-02-13. Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions in NATURE BIOTECHNOLOGY
  • 2018-06-11. p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells in NATURE MEDICINE
  • 2016-04-27. Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9 in NATURE
  • 2017-11-01. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage in NATURE
  • 2017-06-28. Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation in NATURE COMMUNICATIONS
  • 2018-03-19. Base editing with a Cpf1–cytidine deaminase fusion in NATURE BIOTECHNOLOGY
  • 2015-10-05. Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease in NATURE BIOTECHNOLOGY
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