Novel Nucleic Acid Modifier


Ontology type: sgo:Patent     


Patent Info

DATE

2020-10-08T00:00

AUTHORS

CHOUDHARY AMIT , LIM DONGHYUN , KOKKONDA PRAVEEN , LAI SOPHIA , LEE MISEON

ABSTRACT

The present inventions generally relate to site-specific delivery of nucleic acid modifiers and includes novel DNA-binding proteins and effectors that can be rapidly programmed to make site-specific DNA modifications. The present inventions also provide synthetic all-in-one genome editor (SAGE) systems comprising designer DNA sequence readers and a set of small molecules that induce double-strand breaks, enhance cellular permeability, inhibit NHEJ and activate HDR, as well as methods of using and delivering such systems. More... »

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