Anti-Cd96 Antibodies And Methods Of Use Thereof


Ontology type: sgo:Patent     


Patent Info

DATE

2020-06-25T00:00

AUTHORS

CHEN YU , LEE CHINGWEI VIVIAN , FUH-KELLY GERMAINE , YI ZUOAN , HUANG YAO-MING , YEUNG VALENTINE , MCCUTCHEON KRISTA MAUREEN , NALLE SAMUEL , BROUGHTON AUGUSTA ELEANOR , SCHARF LOUISE , SINGH NAVNEET , THAI TINA , XIAO SHOUHUA

ABSTRACT

The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD96 receptor protein (hu-CD96) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD96. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD96 binding to CD155, including effects arising from CD96 interactions with CD226 and/or TIGIT. More... »

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