Compositions And Methods For Inducing Intestinal Stem Cell Regeneration


Ontology type: sgo:Patent     


Patent Info

DATE

2020-04-23T00:00

AUTHORS

ENG GEORGE , WANG FANG , YILMAZ OMER , CHENG CHIA-WEI

ABSTRACT

The present invention provides compositions comprising β-hydroxybutyrate, cyclic or linear β-hydroxybutyrate oligomers, and/or β-hydroxybutyrate ester derivatives, or pharmaceutically-acceptable salts thereof. In various embodiments, the compositions are encapsulated by nanoparticles, such as nanoparticles comprising, e.g., poly(lactic-co-glycolic acid). In additional embodiments, the invention provides methods of using such compositions to induce intestinal stem cell regeneration and/or treat radiation-induced intestinal damage in a subject. More... »

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