Anti-Il1Rap Antibodies And Methods Of Use Thereof


Ontology type: sgo:Patent     


Patent Info

DATE

2020-02-20T00:00

AUTHORS

FOLETTI DAVIDE , KARRER ERIK , FUH-KELLY GERMAINE , IBARRA KRISTIE , ZHENG QUAN , HUANG YAO-MING , DEIS LINDSAY , WOLAK CHRISTINE , BERNS DOMINIC SAMUEL

ABSTRACT

The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human interleukin-1 receptor accessory protein (hu-IL1RAP) and fully block the IL-1, IL-33, and IL-36 intracellular signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided.

Related SciGraph Publications

  • 2019-08-19. IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease in NATURE IMMUNOLOGY
  • 2013-10-30. IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts in MUCOSAL IMMUNOLOGY
  • 2012-02-14. PANDAseq: paired-end assembler for illumina sequences in BMC BIOINFORMATICS
  • 2000-06-20. Human anti-CD30 recombinant antibodies by guided phage antibody selection using cell panning in BRITISH JOURNAL OF CANCER
  • 2005-09-07. Human antibodies from transgenic animals in NATURE BIOTECHNOLOGY
  • 1988-03. Reshaping human antibodies for therapy in NATURE
  • 2005-10-06. Engineering novel binding proteins from nonimmunoglobulin domains in NATURE BIOTECHNOLOGY
  • 2008-10. The IL-33/ST2 pathway: therapeutic target and novel biomarker in NATURE REVIEWS DRUG DISCOVERY
  • 2003-01. Engineered antibodies in NATURE MEDICINE
  • 2007-08-17. FcRn: the neonatal Fc receptor comes of age in NATURE REVIEWS IMMUNOLOGY
  • 2006-01-22. Optimization of humanized IgGs in glycoengineered Pichia pastoris in NATURE BIOTECHNOLOGY
  • 2010-08-29. Structural insights into the assembly and activation of IL-1β with its receptors in NATURE IMMUNOLOGY
  • 1990-12. Phage antibodies: filamentous phage displaying antibody variable domains in NATURE
  • 2016-09-19. Interleukin-33 in health and disease in NATURE REVIEWS IMMUNOLOGY
  • 2010-01-18. The IL-1 family: regulators of immunity in NATURE REVIEWS IMMUNOLOGY
  • 1991-08. Making antibody fragments using phage display libraries in NATURE
  • 2012-05-04. The airway epithelium in asthma in NATURE MEDICINE
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "FOLETTI DAVIDE", 
            "type": "Person"
          }, 
          {
            "name": "KARRER ERIK", 
            "type": "Person"
          }, 
          {
            "name": "FUH-KELLY GERMAINE", 
            "type": "Person"
          }, 
          {
            "name": "IBARRA KRISTIE", 
            "type": "Person"
          }, 
          {
            "name": "ZHENG QUAN", 
            "type": "Person"
          }, 
          {
            "name": "HUANG YAO-MING", 
            "type": "Person"
          }, 
          {
            "name": "DEIS LINDSAY", 
            "type": "Person"
          }, 
          {
            "name": "WOLAK CHRISTINE", 
            "type": "Person"
          }, 
          {
            "name": "BERNS DOMINIC SAMUEL", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ni.1925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026248244", 
              "https://doi.org/10.1038/ni.1925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1054/bjoc.2000.1226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008114327", 
              "https://doi.org/10.1054/bjoc.2000.1226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri.2016.95", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029307492", 
              "https://doi.org/10.1038/nri.2016.95"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030021520", 
              "https://doi.org/10.1038/nbt1178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/332323a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016704652", 
              "https://doi.org/10.1038/332323a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020170410", 
              "https://doi.org/10.1038/nri2155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018390558", 
              "https://doi.org/10.1038/nri2691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/348552a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009781465", 
              "https://doi.org/10.1038/348552a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050233414", 
              "https://doi.org/10.1038/nbt1135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003526811", 
              "https://doi.org/10.1038/nrd2660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/352624a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021945431", 
              "https://doi.org/10.1038/352624a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2737", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017163155", 
              "https://doi.org/10.1038/nm.2737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045032676", 
              "https://doi.org/10.1038/nbt1127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-13-31", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047017534", 
              "https://doi.org/10.1186/1471-2105-13-31"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mi.2013.87", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014635738", 
              "https://doi.org/10.1038/mi.2013.87"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41590-019-0467-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1120397625", 
              "https://doi.org/10.1038/s41590-019-0467-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0103-129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049387641", 
              "https://doi.org/10.1038/nm0103-129"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-02-20T00:00", 
        "description": "

    The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human interleukin-1 receptor accessory protein (hu-IL1RAP) and fully block the IL-1, IL-33, and IL-36 intracellular signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided.

    ", "id": "sg:patent.WO-2020037154-A1", "name": "ANTI-IL1RAP ANTIBODIES AND METHODS OF USE THEREOF", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.420283.f", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/WO-2020037154-A1" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_29.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.WO-2020037154-A1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.WO-2020037154-A1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.WO-2020037154-A1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.WO-2020037154-A1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    125 TRIPLES      14 PREDICATES      32 URIs      8 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.WO-2020037154-A1 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N969698c4308e45cfb296d2d21ff27907
    4 schema:citation sg:pub.10.1038/332323a0
    5 sg:pub.10.1038/348552a0
    6 sg:pub.10.1038/352624a0
    7 sg:pub.10.1038/mi.2013.87
    8 sg:pub.10.1038/nbt1127
    9 sg:pub.10.1038/nbt1135
    10 sg:pub.10.1038/nbt1178
    11 sg:pub.10.1038/ni.1925
    12 sg:pub.10.1038/nm.2737
    13 sg:pub.10.1038/nm0103-129
    14 sg:pub.10.1038/nrd2660
    15 sg:pub.10.1038/nri.2016.95
    16 sg:pub.10.1038/nri2155
    17 sg:pub.10.1038/nri2691
    18 sg:pub.10.1038/s41590-019-0467-1
    19 sg:pub.10.1054/bjoc.2000.1226
    20 sg:pub.10.1186/1471-2105-13-31
    21 schema:datePublished 2020-02-20T00:00
    22 schema:description <p num="0000">The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human interleukin-1 receptor accessory protein (hu-IL1RAP) and fully block the IL-1, IL-33, and IL-36 intracellular signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided.</p>
    23 schema:name ANTI-IL1RAP ANTIBODIES AND METHODS OF USE THEREOF
    24 schema:recipient grid-institutes:grid.420283.f
    25 schema:sameAs https://app.dimensions.ai/details/patent/WO-2020037154-A1
    26 schema:sdDatePublished 2022-09-02T16:21
    27 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    28 schema:sdPublisher Nd2af01ed36414db9b2c60fc7344fdd10
    29 sgo:license sg:explorer/license/
    30 sgo:sdDataset patents
    31 rdf:type sgo:Patent
    32 N20bd9d2f99814ca9921a5ae01160bfdd schema:name BERNS DOMINIC SAMUEL
    33 rdf:type schema:Person
    34 N4365f3ffcbd74d85934346a516fddb14 rdf:first N20bd9d2f99814ca9921a5ae01160bfdd
    35 rdf:rest rdf:nil
    36 N4fb0a87127e8402085ebb7397e7ddf23 rdf:first Ne6f226354cfc4deea21f12d40bd9b48d
    37 rdf:rest Nf9378e2963f84a7f9415c586bf465c8a
    38 N6a64dd04c543471cb072550aefe27f6c rdf:first Nb11791b4eddb440ea479c0f0607a1ff4
    39 rdf:rest N4fb0a87127e8402085ebb7397e7ddf23
    40 N6bf99a466cb048d7bc1aa8190d47c6d6 rdf:first N85ef5c3bd26f433ea44827b6cbba32f4
    41 rdf:rest N8e69f7f2b861464185f3ecf8c42f1a91
    42 N72b9ae4af1004c9fbe3eb8d7da9fe6c5 schema:name IBARRA KRISTIE
    43 rdf:type schema:Person
    44 N85ef5c3bd26f433ea44827b6cbba32f4 schema:name DEIS LINDSAY
    45 rdf:type schema:Person
    46 N8e69f7f2b861464185f3ecf8c42f1a91 rdf:first Nd90e5bc0da9c4e2aa667e79786dd2e15
    47 rdf:rest N4365f3ffcbd74d85934346a516fddb14
    48 N969698c4308e45cfb296d2d21ff27907 rdf:first Na2124aebe62e4ca294b4f8d945ab5d51
    49 rdf:rest N6a64dd04c543471cb072550aefe27f6c
    50 Na2124aebe62e4ca294b4f8d945ab5d51 schema:name FOLETTI DAVIDE
    51 rdf:type schema:Person
    52 Nb11791b4eddb440ea479c0f0607a1ff4 schema:name KARRER ERIK
    53 rdf:type schema:Person
    54 Nd2af01ed36414db9b2c60fc7344fdd10 schema:name Springer Nature - SN SciGraph project
    55 rdf:type schema:Organization
    56 Nd8eafbb1b0bd4494992bdddb49bd37e0 rdf:first Nf67cbd2ec65545d2bbcc1c06ea9e312a
    57 rdf:rest N6bf99a466cb048d7bc1aa8190d47c6d6
    58 Nd90e5bc0da9c4e2aa667e79786dd2e15 schema:name WOLAK CHRISTINE
    59 rdf:type schema:Person
    60 Ne26c88f2262543d8858c276d36dffb1f rdf:first Nf83c2c9a4bcb4aaf97d91c7969451c27
    61 rdf:rest Nd8eafbb1b0bd4494992bdddb49bd37e0
    62 Ne6f226354cfc4deea21f12d40bd9b48d schema:name FUH-KELLY GERMAINE
    63 rdf:type schema:Person
    64 Nf67cbd2ec65545d2bbcc1c06ea9e312a schema:name HUANG YAO-MING
    65 rdf:type schema:Person
    66 Nf83c2c9a4bcb4aaf97d91c7969451c27 schema:name ZHENG QUAN
    67 rdf:type schema:Person
    68 Nf9378e2963f84a7f9415c586bf465c8a rdf:first N72b9ae4af1004c9fbe3eb8d7da9fe6c5
    69 rdf:rest Ne26c88f2262543d8858c276d36dffb1f
    70 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    71 rdf:type schema:DefinedTerm
    72 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    73 rdf:type schema:DefinedTerm
    74 sg:pub.10.1038/332323a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016704652
    75 https://doi.org/10.1038/332323a0
    76 rdf:type schema:CreativeWork
    77 sg:pub.10.1038/348552a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009781465
    78 https://doi.org/10.1038/348552a0
    79 rdf:type schema:CreativeWork
    80 sg:pub.10.1038/352624a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021945431
    81 https://doi.org/10.1038/352624a0
    82 rdf:type schema:CreativeWork
    83 sg:pub.10.1038/mi.2013.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014635738
    84 https://doi.org/10.1038/mi.2013.87
    85 rdf:type schema:CreativeWork
    86 sg:pub.10.1038/nbt1127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045032676
    87 https://doi.org/10.1038/nbt1127
    88 rdf:type schema:CreativeWork
    89 sg:pub.10.1038/nbt1135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050233414
    90 https://doi.org/10.1038/nbt1135
    91 rdf:type schema:CreativeWork
    92 sg:pub.10.1038/nbt1178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030021520
    93 https://doi.org/10.1038/nbt1178
    94 rdf:type schema:CreativeWork
    95 sg:pub.10.1038/ni.1925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026248244
    96 https://doi.org/10.1038/ni.1925
    97 rdf:type schema:CreativeWork
    98 sg:pub.10.1038/nm.2737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017163155
    99 https://doi.org/10.1038/nm.2737
    100 rdf:type schema:CreativeWork
    101 sg:pub.10.1038/nm0103-129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049387641
    102 https://doi.org/10.1038/nm0103-129
    103 rdf:type schema:CreativeWork
    104 sg:pub.10.1038/nrd2660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003526811
    105 https://doi.org/10.1038/nrd2660
    106 rdf:type schema:CreativeWork
    107 sg:pub.10.1038/nri.2016.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029307492
    108 https://doi.org/10.1038/nri.2016.95
    109 rdf:type schema:CreativeWork
    110 sg:pub.10.1038/nri2155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020170410
    111 https://doi.org/10.1038/nri2155
    112 rdf:type schema:CreativeWork
    113 sg:pub.10.1038/nri2691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018390558
    114 https://doi.org/10.1038/nri2691
    115 rdf:type schema:CreativeWork
    116 sg:pub.10.1038/s41590-019-0467-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120397625
    117 https://doi.org/10.1038/s41590-019-0467-1
    118 rdf:type schema:CreativeWork
    119 sg:pub.10.1054/bjoc.2000.1226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008114327
    120 https://doi.org/10.1054/bjoc.2000.1226
    121 rdf:type schema:CreativeWork
    122 sg:pub.10.1186/1471-2105-13-31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047017534
    123 https://doi.org/10.1186/1471-2105-13-31
    124 rdf:type schema:CreativeWork
    125 grid-institutes:grid.420283.f schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...