Methods For Diagnosing And Treating Refractory Celiac Disease Type 2


Ontology type: sgo:Patent     


Patent Info

DATE

2018-03-08T00:00

AUTHORS

CERF-BENSUSSAN, Nadine , MERESSE, Bertrand

ABSTRACT

The present invention relates to methods diagnosing and treating refractory celiac disease type 2 (RCDII). The inventors demonstrated that in a subset of celiac disease patients, intraepithelial lymphocytes with intracellular expression of CD3 (iCD3+ innate IEL) and JAKl or STAT3 gain-of-function mutations display enhanced response to IL-15 and acquire a selective advantage that favors clonal expansion and transformation into lymphoma. In particular, the present invention thus relates to a method for diagnosing RCDII in a patient comprising the detected presence of at least one JAKl or STAT3 gain-of-function mutation in a sample obtained from the patient and concluding that the patient suffers from RCDII when the mutation is detected. More... »

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