Bacteria Engineered To Treat Nonalcoholic Steatohepatitis (Nash)


Ontology type: sgo:Patent     


Patent Info

DATE

2017-08-17T00:00

AUTHORS

MILLER PAUL F , ISABELLA VINCENT M , FALB DEAN , KOTULA JONATHAN W , MACHINANI SUMAN , MILLET YVES , FISHER ADAM B , LI NING , TUCKER ALEX

ABSTRACT

The present disclosure provides engineered bacterial cells comprising a heterologous gene encoding a propionate biosynthesis gene cassette; a butyrate biosynthesis gene cassette; GLP-1; a propionate biosynthesis gene cassette and a butyrate biosynthesis gene cassette; a propionate biosynthesis gene cassette and GLP-1; a butyrate biosynthesis gene cassette and GLP-1; or a propionate biosynthesis gene cassette, a butyrate biosynthesis gene cassette, and GLP- 1. In another aspect, the engineered bacterial cells further comprise a bacterial kill switch. The disclosure further provides pharmaceutical compositions comprising the engineered bacteria, and methods for treating liver disease, such as nonalcoholic steatohepatitis (NASH), using the pharmaceutical compositions of the disclosure. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "MILLER PAUL F", 
        "type": "Person"
      }, 
      {
        "name": "ISABELLA VINCENT M", 
        "type": "Person"
      }, 
      {
        "name": "FALB DEAN", 
        "type": "Person"
      }, 
      {
        "name": "KOTULA JONATHAN W", 
        "type": "Person"
      }, 
      {
        "name": "MACHINANI SUMAN", 
        "type": "Person"
      }, 
      {
        "name": "MILLET YVES", 
        "type": "Person"
      }, 
      {
        "name": "FISHER ADAM B", 
        "type": "Person"
      }, 
      {
        "name": "LI NING", 
        "type": "Person"
      }, 
      {
        "name": "TUCKER ALEX", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm.4102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017481425", 
          "https://doi.org/10.1038/nm.4102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12154-011-0064-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052300988", 
          "https://doi.org/10.1007/s12154-011-0064-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033614077", 
          "https://doi.org/10.1038/nrc3236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep12689", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008653548", 
          "https://doi.org/10.1038/srep12689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10295-015-1627-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011917432", 
          "https://doi.org/10.1007/s10295-015-1627-4"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-08-17T00:00", 
    "description": "

The present disclosure provides engineered bacterial cells comprising a heterologous gene encoding a propionate biosynthesis gene cassette; a butyrate biosynthesis gene cassette; GLP-1; a propionate biosynthesis gene cassette and a butyrate biosynthesis gene cassette; a propionate biosynthesis gene cassette and GLP-1; a butyrate biosynthesis gene cassette and GLP-1; or a propionate biosynthesis gene cassette, a butyrate biosynthesis gene cassette, and GLP- 1. In another aspect, the engineered bacterial cells further comprise a bacterial kill switch. The disclosure further provides pharmaceutical compositions comprising the engineered bacteria, and methods for treating liver disease, such as nonalcoholic steatohepatitis (NASH), using the pharmaceutical compositions of the disclosure.

", "id": "sg:patent.WO-2017139708-A1", "name": "BACTERIA ENGINEERED TO TREAT NONALCOHOLIC STEATOHEPATITIS (NASH)", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.460014.7", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/WO-2017139708-A1" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_24.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.WO-2017139708-A1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.WO-2017139708-A1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.WO-2017139708-A1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.WO-2017139708-A1'


 

This table displays all metadata directly associated to this object as RDF triples.

77 TRIPLES      14 PREDICATES      20 URIs      8 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.WO-2017139708-A1 schema:about anzsrc-for:06
2 anzsrc-for:0605
3 schema:author N1e0e39421e3448f8a7e6108f47bb9f21
4 schema:citation sg:pub.10.1007/s10295-015-1627-4
5 sg:pub.10.1007/s12154-011-0064-8
6 sg:pub.10.1038/nm.4102
7 sg:pub.10.1038/nrc3236
8 sg:pub.10.1038/srep12689
9 schema:datePublished 2017-08-17T00:00
10 schema:description <p num="0000">The present disclosure provides engineered bacterial cells comprising a heterologous gene encoding a propionate biosynthesis gene cassette; a butyrate biosynthesis gene cassette; GLP-1; a propionate biosynthesis gene cassette and a butyrate biosynthesis gene cassette; a propionate biosynthesis gene cassette and GLP-1; a butyrate biosynthesis gene cassette and GLP-1; or a propionate biosynthesis gene cassette, a butyrate biosynthesis gene cassette, and GLP- 1. In another aspect, the engineered bacterial cells further comprise a bacterial kill switch. The disclosure further provides pharmaceutical compositions comprising the engineered bacteria, and methods for treating liver disease, such as nonalcoholic steatohepatitis (NASH), using the pharmaceutical compositions of the disclosure.</p>
11 schema:name BACTERIA ENGINEERED TO TREAT NONALCOHOLIC STEATOHEPATITIS (NASH)
12 schema:recipient grid-institutes:grid.460014.7
13 schema:sameAs https://app.dimensions.ai/details/patent/WO-2017139708-A1
14 schema:sdDatePublished 2022-09-02T16:21
15 schema:sdLicense https://scigraph.springernature.com/explorer/license/
16 schema:sdPublisher Nbdee026ca40a475daf63be00d925b6c3
17 sgo:license sg:explorer/license/
18 sgo:sdDataset patents
19 rdf:type sgo:Patent
20 N0887920bf3224fca896f562efbb707d6 rdf:first N2a2e28eeb7624d6baabb6abe4d9cb55c
21 rdf:rest rdf:nil
22 N0b02e8533a074239a1dd39acfcca5237 rdf:first Naa15ef0504cb4f3a84cb5609a5972989
23 rdf:rest N58476b1be3dd4bf8b36b527fa4473bea
24 N1e0e39421e3448f8a7e6108f47bb9f21 rdf:first Ne54bbbfb696041f8ba9530e5068bbe74
25 rdf:rest Nb8cec4d1d51642c58809e8245518d05d
26 N1f0fdc3cf8c9480c93193b9b52187537 schema:name MACHINANI SUMAN
27 rdf:type schema:Person
28 N2a2e28eeb7624d6baabb6abe4d9cb55c schema:name TUCKER ALEX
29 rdf:type schema:Person
30 N2dc1d515d9a54e2b946c41aa6e2ea7e6 rdf:first N1f0fdc3cf8c9480c93193b9b52187537
31 rdf:rest N0b02e8533a074239a1dd39acfcca5237
32 N54c5841c76e045f1a1437ced9dc3c317 rdf:first Ne964380ddb0a4791bc26f98fdc4e7690
33 rdf:rest Ndcd37e77e9f94de7aacb5a98569f5865
34 N58476b1be3dd4bf8b36b527fa4473bea rdf:first Nfa944ac4bdb347ed81aae764c213aa78
35 rdf:rest Nbfb3ba0fcaff47cda2a79ee2a16392a1
36 N6538549981b14965b7e0c61906fa7d7d schema:name KOTULA JONATHAN W
37 rdf:type schema:Person
38 Naa15ef0504cb4f3a84cb5609a5972989 schema:name MILLET YVES
39 rdf:type schema:Person
40 Nb8cec4d1d51642c58809e8245518d05d rdf:first Nf04f2d5d5a7b49d7bb77331c13c29a88
41 rdf:rest N54c5841c76e045f1a1437ced9dc3c317
42 Nbdee026ca40a475daf63be00d925b6c3 schema:name Springer Nature - SN SciGraph project
43 rdf:type schema:Organization
44 Nbfb3ba0fcaff47cda2a79ee2a16392a1 rdf:first Nd83867ffb9e14f65bc8ecb1c478c7548
45 rdf:rest N0887920bf3224fca896f562efbb707d6
46 Nd83867ffb9e14f65bc8ecb1c478c7548 schema:name LI NING
47 rdf:type schema:Person
48 Ndcd37e77e9f94de7aacb5a98569f5865 rdf:first N6538549981b14965b7e0c61906fa7d7d
49 rdf:rest N2dc1d515d9a54e2b946c41aa6e2ea7e6
50 Ne54bbbfb696041f8ba9530e5068bbe74 schema:name MILLER PAUL F
51 rdf:type schema:Person
52 Ne964380ddb0a4791bc26f98fdc4e7690 schema:name FALB DEAN
53 rdf:type schema:Person
54 Nf04f2d5d5a7b49d7bb77331c13c29a88 schema:name ISABELLA VINCENT M
55 rdf:type schema:Person
56 Nfa944ac4bdb347ed81aae764c213aa78 schema:name FISHER ADAM B
57 rdf:type schema:Person
58 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
59 rdf:type schema:DefinedTerm
60 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
61 rdf:type schema:DefinedTerm
62 sg:pub.10.1007/s10295-015-1627-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011917432
63 https://doi.org/10.1007/s10295-015-1627-4
64 rdf:type schema:CreativeWork
65 sg:pub.10.1007/s12154-011-0064-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052300988
66 https://doi.org/10.1007/s12154-011-0064-8
67 rdf:type schema:CreativeWork
68 sg:pub.10.1038/nm.4102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017481425
69 https://doi.org/10.1038/nm.4102
70 rdf:type schema:CreativeWork
71 sg:pub.10.1038/nrc3236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033614077
72 https://doi.org/10.1038/nrc3236
73 rdf:type schema:CreativeWork
74 sg:pub.10.1038/srep12689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008653548
75 https://doi.org/10.1038/srep12689
76 rdf:type schema:CreativeWork
77 grid-institutes:grid.460014.7 schema:Organization
 




Preview window. Press ESC to close (or click here)


...