Molecular Biomarkers For Cancer Immunotherapy


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

HACOHEN, NIR , ROONERY, Michael, S.

ABSTRACT

In one aspect, provided herein is a method comprising: (a) (i) determining cytolytic activity in a tumor from the subject; and/or (ii) determining genetic alterations associated with cytolytic activity in the tumor; and (b) administering an immunotherapeutic agent to the subject if (i) cytolytic activity is detected in the tumor and/or (ii) a genetic alteration associated with induction of cytolytic activity, tumor resistance to cytolytic activity and/or suppression of cytolytic activity is detected in the tumor. More... »

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In one aspect, provided herein is a method comprising: (a) (i) determining cytolytic activity in a tumor from the subject; and/or (ii) determining genetic alterations associated with cytolytic activity in the tumor; and (b) administering an immunotherapeutic agent to the subject if (i) cytolytic activity is detected in the tumor and/or (ii) a genetic alteration associated with induction of cytolytic activity, tumor resistance to cytolytic activity and/or suppression of cytolytic activity is detected in the tumor.

", "id": "sg:patent.WO-2016100975-A1", "keywords": [ "cancer immunotherapy", "aspect", "method", "cytolytic activity", "Neoplasm", "genetic alteration", "immunotherapeutic agent", "induction", "tumor resistance", "suppression" ], "name": "MOLECULAR BIOMARKERS FOR CANCER IMMUNOTHERAPY", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.32224.35", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/WO-2016100975-A1" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:36", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_c290c18d.jsonl", "type": "Patent" } ]
 

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